Wilson's Disease Clinical Trial
Official title:
A Registered Cohort Study on Wilson's Disease
The aim of this study is to determine the clinical spectrum and natural progression of Wilson's Disease in a prospective multicenter natural history study, to assess the clinical, genetic, epigenetic features and biomarkers of patients with Wilson's Disease to optimize clinical management.
| Status | Recruiting |
| Enrollment | 2000 |
| Est. completion date | December 2049 |
| Est. primary completion date | December 2039 |
| Accepts healthy volunteers | Accepts Healthy Volunteers |
| Gender | All |
| Age group | N/A and older |
| Eligibility |
Inclusion Criteria: - Patients with the genetic diagnosis of Wilson's Disease - Asymptomatic Wilson's Disease carriers - Relatives of Wilson's Disease patients or carriers - Unrelated healthy controls - Participants or Parent(s)/legal guardian(s) willing and able to complete the informed consent process Exclusion Criteria: * Participants are unable to comply with study procedures and visit schedule |
| Country | Name | City | State |
|---|---|---|---|
| China | First Affiliated Hospital of Fujian Medical University | Fuzhou |
| Lead Sponsor | Collaborator |
|---|---|
| Wan-Jin Chen |
China,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | The change of Unified Wilson's Disease Rating Scale (UWDRS) | Disease severity will be assessed by application of the Unified Wilson's Disease Rating Scale (UWDRS), a clinical rating scale consists of three subscales. Higher UWDRS total scores indicate more severe disease. | Up to 30years |
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