Wilson Disease Clinical Trial
Official title:
Clinical Features and Outcome of Wilson's Disease With Generalized Epilepsy in Chinese Patients
Generalized epilepsy is rarely reported in patients with Wilson disease (WD) and lacks experience in clinical practice. We aim to provide better experience for the diagnosis and treatment for WD patients with epilepsy in the future.
A retrospective study was performed in 13 Chinese WD patients with generalized epilepsy. Each patient was diagnosed with WD by clinical evaluation and genetic screening. Patients were given small doses of antiepileptic drugs (AEDs), followed by copper-chelation therapy when the seizures stabilized. Clinical manifestations, brain imaging changes, and treatment and outcome after a long-term follow-up were analyzed. ;
Status | Clinical Trial | Phase | |
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Completed |
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Copper and Molybdenum Balance in Participants With Wilson Disease Treated With ALXN1840
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Phase 2 | |
Completed |
NCT03539952 -
Trientine Tetrahydrochloride (TETA 4HCL) for the Treatment of Wilson's Disease
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Phase 3 | |
Active, not recruiting |
NCT04884815 -
Study of UX701 Gene Transfer for the Treatment of Wilson Disease
|
Phase 1/Phase 2 | |
Not yet recruiting |
NCT03659331 -
A Controlled Study of Potential Therapeutic Effect of Oral Zinc in Manifesting Carriers of Wilson Disease
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N/A | |
Recruiting |
NCT05687474 -
Baby Detect : Genomic Newborn Screening
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Terminated |
NCT05047523 -
Study of ALXN1840 Versus Standard of Care in Pediatric Participants With Wilson Disease
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Phase 3 | |
Completed |
NCT04526210 -
Study of ALXN1840 on the Metabolism of a CYP2B6 Substrate in Healthy Participants
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Phase 1 | |
Completed |
NCT00004338 -
Study of Zinc for Wilson Disease
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Phase 4 | |
Enrolling by invitation |
NCT03655223 -
Early Check: Expanded Screening in Newborns
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Completed |
NCT02273596 -
Efficacy and Safety Study of WTX101 (ALXN1840) in Adult Wilson Disease Patients
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Phase 2 | |
Completed |
NCT02763215 -
The Assessment of Copper Parameters in Wilson Disease Participants on Standard of Care Treatment
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||
Recruiting |
NCT05444127 -
Oral Health and Wilson's Disease: SOMAWI
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Completed |
NCT04408300 -
Study of Retinal Vascular Parameters in Patients With Wilson's Disease
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N/A | |
Active, not recruiting |
NCT05783687 -
Real World Evidence Study in Subjects With Wilson's Disease
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Terminated |
NCT04909346 -
Adeno-Associated Virus (AAV) Antibody Study in Subjects OTC Deficiency, GSDIa, and Wilson Disease
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Completed |
NCT03867526 -
Establishment of Human Cellular Disease Models for Wilson Disease
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||
Enrolling by invitation |
NCT03589820 -
Plasma Exchange and Continuous Hemodiafiltration in Treatment of Wilson's Disease-related Liver Failure
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N/A | |
Completed |
NCT04526197 -
Phase 1 Study of ALXN1840 on the Metabolism of a CYP2C9 Substrate in Healthy Participants.
|
Phase 1 | |
Not yet recruiting |
NCT06430359 -
Circadian Variation of Urinary Copper Excretion in Wilson Disease Patients
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Completed |
NCT04910581 -
rTMS in Wilson Disease Dysarthria
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N/A |