Wilson Disease Clinical Trial
Official title:
A Phase 2, Multi-centre, Open-label, Study to Evaluate the Efficacy and Safety of WTX101 Administered for 24 Weeks in Newly Diagnosed Wilson Disease Patients Aged 18 and Older With an Extension Phase of 36 Months
The main purpose of the study was to evaluate the efficacy of ALXN1840 (formerly WTX101) for 24 weeks on non-ceruloplasmin-bound copper (NCC) concentrations adjusted for molybdenum plasma concentration in participants newly diagnosed with Wilson Disease (WD) who were aged 18 and older and who had NCC concentrations within or above the reference range at the time of enrollment in the study. The study consisted of a 24-week Treatment Period, followed by a planned 36-month Extension Period.
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Status | Clinical Trial | Phase | |
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Completed |
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Phase 2 | |
Completed |
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Phase 3 | |
Active, not recruiting |
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Phase 1/Phase 2 | |
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N/A | |
Recruiting |
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Completed |
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Terminated |
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Phase 3 | |
Completed |
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Study of ALXN1840 on the Metabolism of a CYP2B6 Substrate in Healthy Participants
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Phase 1 | |
Completed |
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|
Phase 4 | |
Enrolling by invitation |
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Early Check: Expanded Screening in Newborns
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Completed |
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The Assessment of Copper Parameters in Wilson Disease Participants on Standard of Care Treatment
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||
Recruiting |
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Completed |
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N/A | |
Active, not recruiting |
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Terminated |
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Adeno-Associated Virus (AAV) Antibody Study in Subjects OTC Deficiency, GSDIa, and Wilson Disease
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Completed |
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Establishment of Human Cellular Disease Models for Wilson Disease
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Enrolling by invitation |
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Plasma Exchange and Continuous Hemodiafiltration in Treatment of Wilson's Disease-related Liver Failure
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N/A | |
Completed |
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|
Phase 1 | |
Not yet recruiting |
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Circadian Variation of Urinary Copper Excretion in Wilson Disease Patients
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Completed |
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rTMS in Wilson Disease Dysarthria
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N/A |