Pencil Beam Scanning in Patients With Renal Tumors

Status Recruiting

Clinical Trial Summary

This is a pilot study to assess acute toxicity in patients receiving flank irradiation using proton therapy for renal tumors.

Clinical Trial Description

Patients with renal tumors including Wilms and clear cell sarcoma of the kidney (CCSK) are treated with multimodality therapy which may include surgery, chemotherapy, and radiation. While long-term disease control is excellent, these patients remain at risk for early and late toxicities partially from radiation. There have been no significant changes to traditional photon radiation fields, which encompass the post-operative bed, anterior abdomen, and vertebral body. Proton beam radiation using pencil beam scanning, which is characterized by Bragg peak dose deposition and high conformality of dose to target regions, is ideally suited to treat the retroperitoneum. This pilot study evaluates pencil beam scanning proton therapy (PBS-PT) to: - result in low acute gastrointestinal toxicity in patients receiving radiation therapy for renal tumors as measured by laboratory evaluations, clinician-assessed, and patient reported health related quality of life outcomes - decrease the duration of radiation therapy - compare doses to organs at risk (OARs) using PBS-PT as compared to traditional photon fields ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03810651
Study type	Interventional
Source	Children's Hospital of Philadelphia
Contact	Christine Hill-Kayser, MD
Phone	215-590-2810
Email	hill@uphs.upenn.edu
Status	Recruiting
Phase	Early Phase 1
Start date	December 26, 2017
Completion date	September 30, 2025

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