Comprehensive Ultrasound Evaluation as a Predictor of Weaning

Status Completed

Clinical Trial Summary

Several studies investigated the role of specific clinical predictors of weaning success, but it is determined by a combination of different aspects that can result in success or failure. Indeed, unresolved lung disease, cardiac dysfunction, loss of respiratory and core muscle strength can play a role in a failure weaning to mechanical ventilation (MV). The investigators hypothesized that a combined score that include heart, lung, and respiratory muscle ultrasound (US) evaluation could be able to predict the ability of weaning success. Furthermore, it will be described weather the days of MV before weaning trial may affect the relevance of each clinical variable evaluated.

Clinical Trial Description

Critically ill patients undergone at least 48 hours of MV and ready to spontaneous breathing trial (SBT) will be included in the study. The spontaneous breathing trial is performed in pressure support ventilation with a clinician-set positive end expiratory pressure (PEEP) ≤ 5 cm H2O and FiO2< 40%. In addition to the parameters traditionally used for the evaluation of weaning (RSBI), the investigators will perform ultrasound evaluation of diaphragm, lung parenchyma, cardiac function, and the strength of the hand grip. Investigators will evaluate the diaphragmatic parameters (thickening fraction,TF, and diaphragmatic displacement, DD) and TFmax (TF during forced breathing /TF during tidal respiration) to identify the inspiratory reserve. Weaning success is considered as liberation from MV within 72 hours. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05539599
Study type	Observational
Source	Università degli Studi di Ferrara
Contact
Status	Completed
Phase
Start date	September 9, 2022
Completion date	May 8, 2024

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02845076` - Weaning From Noninvasive Ventilation	N/A
Completed	`NCT01915563` - Rest After Spontaneous Breathing Trial for Prevention of Post-extubation Failure	N/A
Recruiting	`NCT01721434` - Effects of Levosimendan on Diaphragm Function in Mechanically Ventilated Patients	Phase 2/Phase 3
Completed	`NCT01928277` - Weaning From Mechanical Ventilation: Spontaneous Breathing Trial and the Assessment of Work of Breathing	N/A
Recruiting	`NCT05632822` - Value of Diaphragm Function Predicting Weaning From Mechanical Ventilation
Completed	`NCT03240263` - Inspiratory Muscle Training in Difficult to Wean Patients	N/A
Completed	`NCT06332768` - NIV Versus HFO Versus Standard Therapy Immediately After Weaning From Mechanical Ventilation in ARDS Patients	N/A
Completed	`NCT01867853` - Volume Responsiveness Before SBT Predicts the Outcome of Mechanical Ventilation Weaning in Critically Ill Patients	N/A
Recruiting	`NCT06040138` - Monitoring of Breathing Effort Through Pressure Time Product Measurement Using Airway Occlusion Pressure
Completed	`NCT06224010` - Respiratory Drive and Inspiratory Effort in COVID-19 Associated ARDS
Completed	`NCT03129217` - The Validity of Maximal Diaphragm Thickening Fraction to Measure Diaphragm Function in Mechanically Ventilated Patients
Not yet recruiting	`NCT05431036` - Evaluation of a Combined Model in Predicting Weaning Outcome in Critically Ill Patients.
Completed	`NCT05550220` - A Modified Cuff Leak Test and Reintubation in Mechanically Ventilated Patients	N/A
Recruiting	`NCT05906888` - Weaning With Tracheostomy - an Observational Study on Patient-centered Outcomes
Recruiting	`NCT05944588` - Predictive Value of Chest Ultrasound Observation on Extubation Failure
Not yet recruiting	`NCT05802745` - P0.1 and Extubation Failure in Critically Ill Patients
Recruiting	`NCT03894189` - The Effect of Doxapram Versus Theophylline on Diaphragmatic Function	N/A
Completed	`NCT01877850` - Utility of a Weaning Protocol in ICU	N/A
Completed	`NCT03580720` - Electromyography for Diaphragm Effort	N/A
Recruiting	`NCT03880864` - Lung Ultrasound for Predicting Outcome of Weaning From Mechanical Ventilation	Phase 1