Clinical Trials Logo
  1. Home
  2. Weaning Failure
  3. NCT03505814

Interest of High Flow Nasal Cannula Oxygen Therapy in Pediatric Intensive Care Unit

Weaning Failure Clinical Trial

Official title:
Does High Flow Nasal Cannula Oxygen Therapy Prevent Reintubation in Pediatric Surgical Intensive Care Unit

Clinical Trial Summary

monocentric randomized controlled trial starting from Mars 2017, recruitment is still ongoing. Patients aged between 0-45 days needing mechanical ventilation (MV) with tracheal intubation were included random assignation in two groups for post-extubation management: Group Optiflow (GO) for patients receiving High Flow Nasal Cannula Oxygen Therapy HNFC and Control Group (CG) for conventional treatment.

Patients were evaluated during the first 72h following extubation. Primary endpoint was the incidence of reintubation. Secondary endpoints were incidence of post-extubation respiratory failure, time to reintubate and weaning time from oxygen. Respiratory and hemodynamic parameters were assessed and compared between the two groups upon extubation, after 2 hours (H2), at H6, H12, H24, H36, H48 and H72. Length of stay (LOS) and mortality were also estimated.

Clinical Trial Description

We conducted a monocentric randomized controlled trial starting from Mars 2017, recruitment is still ongoing. Patients aged between 0-45 days needing mechanical ventilation (MV) with tracheal intubation were included regardless type of admission, severity of disease and randomly assigned in two groups for post-extubation management: Group Optiflow (GO) for patients receiving HNFC oxygen therapy and Control Group (CG) for conventional treatment. Before programmed extubation, newborns and young infants received 0.15 mg/kg of Dexamethasone. Patients were evaluated during the first 72h following extubation. Primary endpoint was the incidence of reintubation. Secondary endpoints were incidence of post-extubation respiratory failure, time to reintubate and weaning time from oxygen. Respiratory and hemodynamic parameters were assessed and compared between the two groups upon extubation, after 2 hours (H2), at H6, H12, H24, H36, H48 and H72. Length of stay (LOS) and mortality were also estimated. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03505814
Study type Interventional
Source Hôpital d'enfants Béchir-Hamza
Contact Ben Khalifa Sonia, Pr
Phone 0021698360939
Email benkhalifa_sonia@yahoo.fr
Status Recruiting
Phase N/A
Start date March 1, 2017
Completion date February 28, 2019
View Details
See also
  Status Clinical Trial Phase
Completed NCT05539599 - Comprehensive Ultrasound Evaluation as a Predictor of Weaning
Completed NCT02845076 - Weaning From Noninvasive Ventilation N/A
Completed NCT01915563 - Rest After Spontaneous Breathing Trial for Prevention of Post-extubation Failure N/A
Recruiting NCT01721434 - Effects of Levosimendan on Diaphragm Function in Mechanically Ventilated Patients Phase 2/Phase 3
Completed NCT01928277 - Weaning From Mechanical Ventilation: Spontaneous Breathing Trial and the Assessment of Work of Breathing N/A
Recruiting NCT05632822 - Value of Diaphragm Function Predicting Weaning From Mechanical Ventilation
Completed NCT06332768 - NIV Versus HFO Versus Standard Therapy Immediately After Weaning From Mechanical Ventilation in ARDS Patients N/A
Completed NCT03240263 - Inspiratory Muscle Training in Difficult to Wean Patients N/A
Completed NCT01867853 - Volume Responsiveness Before SBT Predicts the Outcome of Mechanical Ventilation Weaning in Critically Ill Patients N/A
Recruiting NCT06040138 - Monitoring of Breathing Effort Through Pressure Time Product Measurement Using Airway Occlusion Pressure
Completed NCT06224010 - Respiratory Drive and Inspiratory Effort in COVID-19 Associated ARDS
Completed NCT03129217 - The Validity of Maximal Diaphragm Thickening Fraction to Measure Diaphragm Function in Mechanically Ventilated Patients
Not yet recruiting NCT05431036 - Evaluation of a Combined Model in Predicting Weaning Outcome in Critically Ill Patients.
Completed NCT05550220 - A Modified Cuff Leak Test and Reintubation in Mechanically Ventilated Patients N/A
Recruiting NCT05906888 - Weaning With Tracheostomy - an Observational Study on Patient-centered Outcomes
Recruiting NCT05944588 - Predictive Value of Chest Ultrasound Observation on Extubation Failure
Not yet recruiting NCT05802745 - P0.1 and Extubation Failure in Critically Ill Patients
Recruiting NCT03894189 - The Effect of Doxapram Versus Theophylline on Diaphragmatic Function N/A
Completed NCT01877850 - Utility of a Weaning Protocol in ICU N/A
Completed NCT03580720 - Electromyography for Diaphragm Effort N/A