Effects of Total Parenteral Nutrition on Skeletal Muscle Genomics.

Wasting;Muscle(S) Clinical Trial

Official title:

Effects of Total Parenteral Nutrition on Skeletal Muscle Genomics.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03401944
• Other study ID #: MB1+2
• Status: Completed
• Phase: N/A
• First received: December 21, 2017
• Last updated: January 22, 2018
• Start date: January 1, 2005
• Est. completion date: December 31, 2014

Study information

• Verified date: January 2018
• Source: Göteborg University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The study investigates effects related to muscle protein metabolism at provision of Total Parenteral nutrition.

Description:

Randomized study investigating alterations in muscle protein metabolism at provision of parenteral nutrition. The study uses a genomic/transcriptomic/proteomic approach to evaluate factors related to activation of skeletal muscle protein synthesis. Patients scheduled for major gastrointestinal surgery are included. Muscle specimens are collected during surgery.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 24
• Est. completion date: December 31, 2014
• Est. primary completion date: December 31, 2014
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years to 85 Years

Eligibility

Inclusion Criteria:

• Major gastrointestinal surgery

• Assumed need of post-operative artificial nutrition.

Exclusion Criteria:

• Insulin dependent diabetes

• Steroid medication

Related Conditions & MeSH terms

• Muscular Atrophy
• Wasting;Muscle(S)

Intervention

Drug:
• TPN

Other:
• Control

Locations

Country	Name	City	State
Sweden	Department of Surgery	Göteborg

Sponsors (1)

Lead Sponsor	Collaborator
Göteborg University

Country where clinical trial is conducted

Sweden, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Muscle protein metabolism	Alterations in muscle protein metabolism will be assessed by various standard techniques for gene and protein expression. Combined measurements of cell-signaling molecules representing anabolic and catabolic signaling pathways will be evaluated in relation to transcription of muscle myosin proteins.	Single evaluation point at 12-14 hours following the start of overnight infusion.