Warts Clinical Trial
Official title:
Salicylic Acid Versus Cryotherapy for the Treatment of HPV1-induced Plantar Warts: a Randomized Controlled Trial
To evaluate whether salicylic acid was superior to cryotherapy for plantar warts
Status | Not yet recruiting |
Enrollment | 174 |
Est. completion date | November 2022 |
Est. primary completion date | November 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 12 Years and older |
Eligibility | Inclusion Criteria: - Patients with HPV1-induced plantar warts. - Total number of warts is =5. - Aged 12 years or older. Exclusion Criteria: - Patients are currently participating in another trial for the treatment of plantar warts. - Patients had received two or more consecutive sessions of cryotherapy, with an interval of no more than 4 weeks (The history of salicylic acid treatment was not considered as criteria for exclusion because high concentration salicylic acid is not commercially available in Chinese mainland). - Patients have taken immunosuppressant drugs (such as oral corticosteroids) during the past three months. - Patients have impaired healing eg due to diabetes, vitamin A deficiency, hyperthyroidism and hypothyroidism. - Patients have autoimmune diseases (such as systemic lupus erythematosus, dermatomyositis, scleroderma or other diseases). - Patients are pregnant or ready for pregnancies or breast-feeding. - Patients have cold intolerance (such as cold urticaria, cryoglobulinaemia, cold agglutinin syndrome or Raynaud's syndrome). - Patients have local pain intolerance. - Patients have local hypoesthesia. - Patients are unable to tolerate salicylic acid or cryotherapy. |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
The 306 Hospital of People's Liberation Army |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | cure rate at 12 weeks | A patient was considered to be cured if all warts were no longer visible and could not be palpated anymore. | 12 weeks since the initial treatment | |
Secondary | time to clearance of warts | The time from treatment initiation until clearance of all warts | 12 weeks since the initial treatment | |
Secondary | patient satisfaction with the treatment | Patient satisfaction was rated on a 5-point scale (from very happy to very unhappy) | 12 weeks since the initial treatment | |
Secondary | treatment-related adverse events | Some adverse effects, including pain, swelling, blisters, hemorrhagic bullae, bruising, and skin breakdown, were recorded by the patients, whereas others, including secondary bacterial infection, hyperpigmentation, hypopigmentation, and scarring were evaluated by a dermatologist | 12 weeks since the initial treatment |
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