Vulvovaginal Candidiasis Clinical Trial
Official title:
Monthly Itraconazole Versus Classic Homeopathy for the Treatment of Recurrent Vulvovaginal Candidiasis: a Randomised Trial
A prospective study to evaluate the efficacy of classic homeopathic therapy compared to maintenance itraconazole therapy with and without additional exogenous lactobacillus for treatment of recurrent Candida vaginitis.
Objective:
Antimycotics effectively treat sporadic and recurrent vulvovaginal candidiasis (RVVC).
Classic homeopathy (CH) is also used to treat this condition. We compared the efficacy of CH
and itraconazole in reducing the frequency of RVVC episodes.
Design:
Single-centre, prospective, randomized.
Sample:
One-hundred-and-fifty patients with a history of RVVC and an acute episode of VVC.
Methods:
Women were randomised into 3 groups: itraconazole with lactobacilli (group 1), itraconazole
without lactobacilli (group 2) and CH (group 3). Itraconazole treatment of acute infection
was followed by a 6-months maintenance regimen with monthly single-day itraconazole (200 mg
bid). Thereafter, patients were followed without treatment for 6 months. Women in group 1
were given additional vaginal lactobacilli for six days per month. CH treatment was
performed for 12 months.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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