Von Willebrand Diseases Clinical Trial
Inclusion criteria: Only constitutional VWD-patients fulfilling the inclusion criteria of the
French reference center for VWD will be included. Patients with acquired von Willebrand
syndrome will not be included.
Material and Methods: A 15-items survey that will be sent to the 30 centers involved in the
French network for bleeding disorders (MHEMO) to identify VWD-patients referred for
endoscopic exploration of at least one GI-bleeding from January 2015 to December 2017. Only
constitutional VWD-patients fulfilling the inclusion criteria of the French reference center
for VWD will be included. Constitutional VWD diagnosis will be confirmed confirmed centrally
in all patients by the French reference center for von Willebrand disease. A GI-bleeding
episode will be defined as any overt or occult GI-bleeding (unexplained chronic iron
deficiency anemia causing a drop of hemoglobin level by more than 2 g/dL from baseline). We
will analyze patient characteristics, GI-bleeding pattern, VWD type/subtype, nature
(gastroscopy, colonoscopy or VCE) and results of the endoscopic exploration and management
that was applied: endoscopic therapy by argon plasma coagulation, on-demand/prophylactic-VWF
replacement therapy, use of antiangiogenic drugs. If angiodysplasia without another bleeding
source is identified, GI-bleeding will be categorized as angiodysplasia, if another lesion is
identified GI-bleeding will be categorized as "no-angiodysplasia" and if no bleeding source
is identified, GI-bleeding will be categorized as obscure GI-bleeding. Recurrence will be
defined as evidence of overt GI-bleeding or a drop of hemoglobin level by more than 2 g/dL
from baseline.
n/a
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