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Vomiting clinical trials

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NCT ID: NCT00381862 Completed - Colorectal Cancer Clinical Trials

Phase II Trial Evaluating the Efficacy and Tolerability of Aprepitant & Palonosetron for Prevention of Chemotherapy-Induced Nausea and Vomiting

Start date: June 2006
Phase: Phase 2
Study type: Interventional

RATIONALE: Aprepitant, palonosetron, and dexamethasone may help lessen or prevent nausea and vomiting in patients receiving chemotherapy. PURPOSE: This phase II trial is studying how well giving aprepitant together with palonosetron and dexamethasone works in preventing nausea and vomiting caused by chemotherapy in patients receiving chemotherapy for metastatic colorectal cancer.

NCT ID: NCT00366834 Completed - Nausea Clinical Trials

Intravenous And Oral Casopitant (GW679769) For The Prevention Of Chemotherapy Induced Nausea And Vomiting

Start date: July 2006
Phase: Phase 3
Study type: Interventional

This is a Phase III trial designed to demonstrate that casopitant (GW679769) plus dexamethasone and ondansetron is more effective in the prevention of vomiting than dexamethasone and ondansetron alone following the administration of moderately emetogenic chemotherapy.

NCT ID: NCT00362648 Completed - Diarrhea Clinical Trials

Developing World Study for RotaTeqâ„¢ (V260-015)(COMPLETED)

Start date: March 2007
Phase: Phase 3
Study type: Interventional

The purpose of the current study is to evaluate whether the vaccine is effective, well-tolerated and immunogenic among infants in developing countries.

NCT ID: NCT00359177 Completed - Vomiting Clinical Trials

Observational Study Evaluating The Processing Or Breakdown Of GW679769 In Subjects With Hepatic Impairment

Start date: December 1, 2005
Phase: Phase 1
Study type: Interventional

The purpose of the study is to evaluate how subjects with mild or moderate liver problems process or breakdown the study drug GW679769 in their bodies as compared to healthy subjects.

NCT ID: NCT00358813 Completed - Vomiting Clinical Trials

Observational Pharmacokinetic Study Of GW679769 In Subjects With Renal Impairment

Start date: September 8, 2006
Phase: Phase 1
Study type: Interventional

The purpose of the study is to evaluate how subjects with mild or moderate kidney problems process or breakdown the study drug GW679769 in their bodies as compared to healthy subjects.

NCT ID: NCT00343863 Completed - Clinical trials for Stage IIIA Breast Cancer

Dexamethasone and Ondansetron Hydrochloride or Palonosetron Hydrochloride in Preventing Nausea and Vomiting in Patients Receiving Doxorubicin Hydrochloride and Cyclophosphamide For Early Stage Breast Cancer

Start date: January 2006
Phase: N/A
Study type: Interventional

RATIONALE: Antiemetic drugs, such as dexamethasone, ondansetron hydrochloride, and palonosetron hydrochloride, may help lessen or prevent nausea and vomiting caused by chemotherapy. PURPOSE: This clinical trial studies how well giving dexamethasone together with ondansetron hydrochloride or palonosetron hydrochloride works in preventing nausea and vomiting in patients receiving doxorubicin hydrochloride and cyclophosphamide for early stage breast cancer

NCT ID: NCT00343460 Completed - Clinical trials for Unspecified Adult Solid Tumor, Protocol Specific

APF530 or Palonosetron Combined With Dexamethasone in Preventing Nausea and Vomiting in Patients Receiving Chemotherapy for Cancer

Start date: April 2006
Phase: Phase 3
Study type: Interventional

RATIONALE: Antiemetic drugs, such as APF530, palonosetron, and dexamethasone, may help lessen or prevent nausea and vomiting in patients receiving chemotherapy for cancer. It is not yet known whether APF530 is more effective than palonosetron when given together with dexamethasone in preventing nausea and vomiting caused by chemotherapy. PURPOSE: This randomized phase III trial is studying APF530 and dexamethasone to see how well they work compared with palonosetron and dexamethasone in preventing nausea and vomiting in patients receiving chemotherapy for cancer.

NCT ID: NCT00337727 Completed - Clinical trials for Chemotherapy-Induced Nausea and Vomiting

Aprepitant for the Prevention of Chemotherapy Induced Nausea and Vomiting (CINV)(0869-130)(COMPLETED)

Start date: January 2007
Phase: Phase 3
Study type: Interventional

The study will test aprepitant for the prevention of CINV in patients receiving their initial cycle of Moderately Emetogenic Chemotherapy (MEC). Patients receiving more then one cycle of chemotherapy may opt to participate in an optional second cycle during which the patient will receive the same antiemetic regimen as cycle 1, except that an IV formulation of aprepitant will be given in place of the oral formulation on study day one. Study drug administration on subsequent days will be given orally as in cycle 1.

NCT ID: NCT00334152 Completed - Clinical trials for Postoperative Nausea and Vomiting

Casopitant And ZOFRAN To Prevent Post Operative Nausea And Vomiting In Women

Start date: March 2006
Phase: Phase 3
Study type: Interventional

This study is being conducted to see if adding GW679769 (casopitant) to ZOFRAN will significantly decrease the number of patients who experience nausea and vomiting after surgery.

NCT ID: NCT00326248 Completed - Clinical trials for Nausea and Vomiting, Postoperative

Casopitant (Oral) And ZOFRAN To Prevent Postoperative Nausea And Vomiting In Women

Start date: March 2006
Phase: Phase 3
Study type: Interventional

This study is being conducted to see if adding GW679769 (casopitant) to ZOFRAN will significantly decrease the number of patients who experience nausea and vomiting after surgery.