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Vocal Cord Paralysis clinical trials

View clinical trials related to Vocal Cord Paralysis.

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NCT ID: NCT06406725 Recruiting - Clinical trials for Vocal Cord Dysfunction

Detection of Vocal Fold Motion Impairment on Noninvasive Positive Pressure

Start date: March 30, 2024
Phase:
Study type: Observational

The goal of this prospective, observational study is to evaluate for the presence of vocal fold motion impairment (VFMI) in the children admitted to the pediatric intensive care unit on noninvasive positive pressure ventilation (NIV PPV). Participants will have two ultrasounds of their vocal folds performed, once while on NIV PPV and once after weaned off of the NIV PPV. This results of these scans will be reviewed against one another and against the gold standard, fiberoptic nasolaryngoscopy (FNL). The main question this study aims to answer is: Can POCUS be used to reliably detect VFMI while pediatric patients on supported with NIV PPV?

NCT ID: NCT06227039 Recruiting - Pain, Acute Clinical Trials

Patient Augmented Reality and Vibratory Array Otorhinolaryngology Procedures

PARVA
Start date: October 1, 2022
Phase: N/A
Study type: Interventional

In-office procedures (IOPs) are a cost-effective, and safe alternative to many operating room procedure, with benefits such as reduced anesthesia risk. One of the major causes of failed in-office procedures or requirement of conversion to the operating room is poor patient tolerance. Vibration and augmented reality (AR) can be used as non-pharmacologic treatment options to treat patient anxiety and pain by using the physiology proposed by the gate-way theory of pain as well as distraction. This study seeks to compare anxiety and pain perception with patient reported survey data, as well as physiologic indicators of stress such as heart rate variability (HRV) within patients undergoing IOPs in a laryngology office with and without vibration and AR treatment.

NCT ID: NCT06007170 Recruiting - Clinical trials for Bilateral Vocal Cord Paralysis

Performance of the SPIRION Laryngeal Pacemaker in BVFP Patients Without Glottal Enlargement

Start date: July 27, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical investigation is to learn about the use of a novel medical device, the SPIRION Laryngeal Pacemaker, in patients suffering from bilateral vocal fold paralysis (BVFP). The main questions it aims to answer are: - Is the use of the device safe? - Does the device improve the participants ability to take a breath? Participants will be implanted with the SPIRION Laryngeal Pacemaker and the development of their symptoms will be observed for the following 2 years.

NCT ID: NCT06007144 Recruiting - Clinical trials for Bilateral Vocal Cord Paralysis

Performance of the SPIRION Laryngeal Pacemaker in BVFP Patients With Single-sided Glottal Enlargement

Start date: August 18, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical investigation is to learn about the use of a novel medical device, the SPIRION Laryngeal Pacemaker, in patients suffering from bilateral vocal fold paralysis (BVFP) and who have had at least one related surgery on one of their vocal folds. The main questions it aims to answer are: - Is the use of the device safe? - Does the device improve the participants ability to take a breath? Participants will be implanted with the SPIRION Laryngeal Pacemaker and the development of their symptoms will be observed for the following 2 years.

NCT ID: NCT05963165 Recruiting - Clinical trials for Unilateral Vocal Cord Paralysis

Non-phonatory Exercises in Patients With Unilateral Vocal Fold Paralysis Post-thyroidectomy

ENFP
Start date: July 1, 2023
Phase: N/A
Study type: Interventional

Thyroidectomy is the most common iatrogenic cause of vocal fold paralysis. Patients complain of hoarseness caused by incomplete glottic closure and have effort to raise vocal intensity with consequent elevation of the larynx and/or involvement of supraglottic structures in phonation. These compensation mechanisms result in a shift of the fundamental frequency towards more serious tones or falsetto voice emissions. The first choice treatment is speech therapy which aims to obtain better glottic closure, preventing ankylosis of the crico-arytenoid joint. In order to promote better glottic closure without risking the onset or increase of dysfunctional compensation, the idea behind this project is to propose non-phonatory adduction exercises in the first post-operative week. The primary objective of the study is to compare patients who will perform non-phonatory exercises in parallel with medical therapy for one week and patients who will perform standard medical therapy only during the first week.

NCT ID: NCT05542550 Recruiting - Clinical trials for Vocal Cord Paralysis

Voice Rest and Injection Laryngoplasty

Start date: August 1, 2023
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the subjective, objective, and aerodynamic impact of voice rest following injection augmentation and compare the outcomes to patients with no post-procedure voice restrictions.

NCT ID: NCT05119842 Recruiting - Clinical trials for Paralysis, Unilateral, Vocal Cord

APrevent-VOIS-Implant-002 - a Two-Part, Open-Label, Non-Randomized Multicenter Study

Start date: November 13, 2019
Phase: N/A
Study type: Interventional

This is a prospective, 2-part, multi-center, open-label, non-randomized clinical trial to assess safety and effectiveness of APrevent® VOIS Implants for the treatment of patients with Unilateral Vocal Fold Paralysis (UVFP). In total 30 evaluable patients are planned to be enrolled.

NCT ID: NCT04700566 Recruiting - Vocal Fold Palsy Clinical Trials

Allograft Adipose Injectable for Vocal Fold Paralysis

Start date: May 16, 2022
Phase: Phase 3
Study type: Interventional

Renuva is allograft adipose matrix commonly used as a filler in cosmetic procedures. The investigators are studying this material as an injectable in the vocal fold to treat glottic insufficiency. Currently, many products can be used as an injectable in the vocal fold to correct glottic insufficiency such as carbomethycellulose, hyaluronic acid, collagen derivatives and calcium hydroxyapatite amongst others. An ideal injectable would not impair the fibroelastic property of the vocal fold tissues and would integrate within the tissue of the vocal fold. Since Renuva has the property of stimulating adipogenesis by using growth factor and collagen, the investigators believe it could represent a good option in terms of safety and efficacy for vocal fold augmentation. This study will assess the safety and efficacy of Renuva as a vocal fold injectable to treat glottic insufficiency.

NCT ID: NCT04396912 Recruiting - Thyroid Cancer Clinical Trials

Post-thyroidectomy Vocal Cord Paralysis Along With Hypocalcemia: STROBE - Guided Prospective Cohort

Start date: May 15, 2020
Phase:
Study type: Observational

In the present study, the severity of recurrent laryngeal nerve injury (RLNI) and hypocalcemia (H) will be followed-up and the probable interrelation between them will be proposed considering the clinical situation of patients, e.g. improvement in hypocalcemia also make a positive effect on voice? (any objective sign? Ca? PTH?), return of voice is parallel with the improvement in hypocalcemia? Postoperative calcium (Ca), parathyroid hormone (PTH), regular vocal cord evaluations by ear-nose-throat (ENT) exams, deterioration-stability-improvement of clinical symptoms regarding both Ca metabolism and vocal cord function will be noted at regular intervals (postoperative day 1-3-first, weekly control/first month, monthly/first 6-month, 3-monthly/6-12 months) at outpatient controls. Serum Ca, PTH, ENT evaluation of vocal cords-noted.

NCT ID: NCT03980275 Recruiting - Clinical trials for Bilateral Vocal Cord Paralysis

Selective Laryngeal Reinnervation for Bilateral Vocal Fold Paralysis

Start date: December 10, 2019
Phase:
Study type: Observational

This is a prospective observational study examining the treatment outcomes of selective laryngeal reinnervation procedures for patients with bilateral vocal fold paralysis.