Assessment of Hypoxia Inducible Factor and Autophagy Related Genes in Patients With Non-Segmental Vitiligo

Vitiligo Clinical Trial

Official title:

Assessment of Hypoxia Inducible Factor and Autophagy Related Genes in Patients With Non-Segmental Vitiligo

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06410898
• Other study ID #: Soh-Med-24-04-014MS
• Status: Recruiting
• Phase: N/A
• Start date: April 25, 2024
• Est. completion date: July 25, 2024

Study information

• Verified date: May 2024
• Source: Sohag University
• Contact: Rania H Metwally, Resident
• Phone: 01018845428
• Email: rania_hassan_post[@]med.sohag.edu.eg
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The present study will aim to evaluate:

1. The presence of Hypoxia Inducible Factor in vitiligo patient

2. Defect of Autophagy Related Genes in vitiligo patient

3. The cross relation between Autophagy Related Genes and Hypoxia Inducible Factor in the pathogenesis of vitiligo among Egyptian patients in Sohag Governorate

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 30
• Est. completion date: July 25, 2024
• Est. primary completion date: July 25, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• Adult >18 years

• With non segmental vitiligo

• A group of participants will be included as a control group

Exclusion Criteria:

• Pregnancy

• Patient with chronic inflammatory skin disorders

• patient on anti-oxidant or anti-inflammatory drugs

• patient on topical or systemic treatment for vitiligo in last 4 weeks

• patients with other autoimmune diseases

• patients with diabetes mellitus

Related Conditions & MeSH terms

• Hypoxia
• Vitiligo

Intervention

Device:
• Punch Biopsy 5mm
Disinfect the skin, inject local anesthesia ,insert the punch and extract the biopsy

Locations

Country	Name	City	State
Egypt	Sohag University hospitals	Sohag

Sponsors (1)

Lead Sponsor	Collaborator
Sohag University

Country where clinical trial is conducted

Egypt, 

References & Publications (4)

Agarwal S, Ganesh S. Perinuclear mitochondrial clustering, increased ROS levels, and HIF1 are required for the activation of HSF1 by heat stress. J Cell Sci. 2020 Jul 9;133(13):jcs245589. doi: 10.1242/jcs.245589. — View Citation

Artika IM, Dewi YP, Nainggolan IM, Siregar JE, Antonjaya U. Real-Time Polymerase Chain Reaction: Current Techniques, Applications, and Role in COVID-19 Diagnosis. Genes (Basel). 2022 Dec 16;13(12):2387. doi: 10.3390/genes13122387. — View Citation

Bastonini E, Kovacs D, Raffa S, Delle Macchie M, Pacifico A, Iacovelli P, Torrisi MR, Picardo M. A protective role for autophagy in vitiligo. Cell Death Dis. 2021 Mar 25;12(4):318. doi: 10.1038/s41419-021-03592-0. — View Citation

Ezzedine K, Lim HW, Suzuki T, Katayama I, Hamzavi I, Lan CC, Goh BK, Anbar T, Silva de Castro C, Lee AY, Parsad D, van Geel N, Le Poole IC, Oiso N, Benzekri L, Spritz R, Gauthier Y, Hann SK, Picardo M, Taieb A; Vitiligo Global Issue Consensus Conference Panelists. Revised classification/nomenclature of vitiligo and related issues: the Vitiligo Global Issues Consensus Conference. Pigment Cell Melanoma Res. 2012 May;25(3):E1-13. doi: 10.1111/j.1755-148X.2012.00997.x. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Assessment of Autophagy Related genes in Vitiligo patients	Assess Autophagy Related genes levels in skin biopsy of vitiligo patient	2 months
Primary	Assessment of Hypoxia Inducible Factor in Vitiligo patients	Assess level of Hypoxia Inducible factor in skin biopsy of vitiligo patient	2 months