Vitiligo Clinical Trial
Official title:
Randomized, Split-Body, Single-Blinded Clinical Trial of Narrow Band-Ultraviolet B (NB-UVB) Treatment for Vitiligo
The objective of this study is to assess the effectiveness and safety of narrowband-ultraviolet B (NB-UVB) treatment in adult subjects with vitiligo.
Vitiligo is a chronic acquired cutaneous disease of pigmentation that affects patients'
quality of life across all degrees of involvement and severity. Phototherapy is a clinically
indicated treatment for skin lesions. Treatments are usually administered in an outpatient
setting, typically three times per week. This is a proof-of-concept study as there are few
well-designed prospective clinical studies showing the efficacy of NB-UVB phototherapy in the
treatment of vitiligo in terms of repigmentation and quality of life. The following are the
proposed objectives of this study:
1. NB-UVB phototherapy improves vitiligo with at least 50% repigmentation compared to no
treatment on affected areas of the trunk and extremities over 24 weeks.
2. NB-UVB phototherapy leads to improvement in quality of life as measured by standardized
quality of life metrics (DLQI and Skindex-29) over 24 weeks.
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