Vitiligo Vulgaris Clinical Trial
Official title:
The Effect of Preceding Fractional Co2 Laser Either With Tacrolimus, Calcipotriol or With NB-UVB in the Treatment of Stable Generalized Vitiligo
Vitiligo is an acquired disorder of the skin and mucous membranes characterized by well
circumscribed depigmented macules and patches that occur secondary to selective destruction
of melanocytes (Zhang et al., 2009).
Generalized vitiligo is the most common clinical presentation and often involves the face and
acral regions (Alikhan et al., 2011).
Combined vitiligo treatments have been found to be superior to monotherapies regarding
efficacy, early response and safety (Kandaswamy et al., 2013).
Fractionated lasers represent a new modality for skin resurfacing based on the theory of
fractional photothermolysis introduced by Manstein et al (2004). These lasers were shown to
be efficient in treating facial photo aging changes as well as scars, and have an improved
safety and recovery profile compared with traditional CO2 laser resurfacing. Fractionated
lasers do not ablate the entire epidermis and thereafter leave intact skin between coagulated
necrotic columns. This characteristic facilitates the skin healing process (Bogdan et al.,
2010)
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT00907062 -
Ginkgo Biloba for the Treatment of Vitiligo Vulgaris in Adolescents
|
Phase 1 | |
| Completed |
NCT00372307 -
Efficacy and Safety of Pimecrolimus for the Treatment of Vitiligo Vulgaris
|
Phase 2 | |
| Completed |
NCT01401374 -
Online Health Survey of Patients With Vitiligo Vulgaris/ Online Survey of Pediatric Patients With Vitiligo
|
N/A | |
| Completed |
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Questionnaire and Laboratory Data on Vitiligo Vulgaris
|
N/A |