Vitamin D Deficiency Clinical Trial
Official title:
Assessment of Serum Vitamin D Levels in Surgical Adolescent Idiopathic Scoliosis Patients
This study aims to estimate the prevalence of vitamin D insufficiency among patients with adolescent idiopathic scoliosis, to calculate the differences in serum vitamin D levels, Cobb angles, spinal bone mass densities, and serum alkaline phosphatase levels between genders in the sample, and to assess the possibility of a correlation between any of these factors in those surgical patients.
Adolescent Idiopathic Scoliosis (AIS) is a major public health problem and despite its
relative rareness, it reduces the quality of life. It is three-dimensional deformity where
there is a lateral curving of the spine. The prevalence rate is 0.47-5.2%. The degree of the
spinal curvature is evaluated by the Cobb angle. A Cobb angle of more than 10-15° is
considered pathological. AIS occurs mostly in adolescents between 10 and 25 years of age, and
is more prevalent among females.
Scoliosis is considered severe and requires surgical intervention when the Cobb angle exceeds
40o.
The etiology of AIS is still unknown. Genetic and non-genetic factors have been attributed to
cause AIS. Among non-genetic factors is bone mineral density (BMD), as bone quality plays an
important role in the derangement of bony mechanical stability. The prevalence of AIS with
osteoporosis is approximately 20-38%. Osteoporosis is known to lower the bone strength.
Vitamin D plays an essential role in maintaining a healthy mineralized skeleton. It helps
with calcium absorption, and patients with a deficiency of Vitamin D can have difficulties in
producing new bone and maintaining their bone strength.
In this study, the prevalence of vitamin D insufficiency among patients with AIS was
evaluated. Gender differences in serum vitamin D levels, Cobb angles, BMD, and serum alkaline
phosphatase levels were measured. Further correlation of Vitamin D with Cobb angles, BMD, and
serum ALP levels was also evaluated.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT04244474 -
Effect of Vitamin D Supplementation on Improvement of Pneumonic Children
|
Phase 1/Phase 2 | |
| Recruiting |
NCT05459298 -
ViDES Trial (Vitamin D Extra Supplementation)
|
N/A | |
| Completed |
NCT04476511 -
The Efficacy and the Safety of Vitamin D3 30,000 IU for Loading Dose Schedules
|
Phase 3 | |
| Suspended |
NCT03652987 -
Endocrine and Menstrual Disturbances in Women With Polycystic Ovary Syndrome (PCOS)
|
||
| Completed |
NCT03920150 -
Vitamin D 24'000 IU for Oral Intermittent Supplementation
|
Phase 3 | |
| Completed |
NCT03264625 -
The Effects of Oral Vitamin D Supplementation on the Prevention of Peritoneal Dialysis-related Peritonitis
|
Phase 2 | |
| Completed |
NCT04183257 -
Effect of Escalating Oral Vitamin D Replacement on HOMA-IR in Vitamin D Deficient Type 2 Diabetics
|
Phase 4 | |
| Recruiting |
NCT05084248 -
Vitamin D Deficiency in Adults Following a Major Burn Injury
|
Phase 4 | |
| Completed |
NCT05506696 -
Vitamin D Supplementation Study
|
N/A | |
| Completed |
NCT00092066 -
A Study to Evaluate the Safety, Tolerability, and Efficacy of an Investigational Drug and Dietary Supplement in Men and Postmenopausal Women With Osteoporosis (0217A-227)
|
Phase 3 | |
| Completed |
NCT03234218 -
Vitamin D Levels in Liver Transplantation Recipients Prospective Observational Study
|
||
| Completed |
NCT03203382 -
Corneal Nerve Structure in Sjogren's
|
||
| Completed |
NCT02714361 -
A Study to Investigate the Effect of Vitamin D3 Supplementation on Iron Status in Iron Deficient Women
|
N/A | |
| Completed |
NCT02906319 -
Vitamin D and HbA1c Levels in Diabetic Patients With CKD
|
N/A | |
| Completed |
NCT02118129 -
Vitamin D Among Young Adults: an Intervention Study Using a Mobile 'App'.
|
N/A | |
| Not yet recruiting |
NCT01419821 -
Vitamin D and Its Affect on Growth Rates and Bone Mineral Density Until Age 5
|
N/A | |
| Completed |
NCT02187146 -
The Effects of Serum Vitamin D and IVF Outcome
|
N/A | |
| Completed |
NCT02275650 -
The Role of Narrowband Ultraviolet B Exposure in the Maintenance of Vitamin D Levels During Winter
|
N/A | |
| Completed |
NCT01741181 -
Vitamin D Supplementation in Patients With Diabetes Mellitus Type 2
|
Phase 4 | |
| Completed |
NCT01651000 -
Safety and Efficacy of CTAP101 to Treat Secondary Hyperparathyroidism in Stage 3 or 4 CKD and Vitamin D Insufficiency
|
Phase 3 |