Vitamin D Deficiency Clinical Trial
Official title:
The Effect of D Vitamin Status on Different Neuromuscular Blocker Agents Reverse Time
Verified date | November 2018 |
Source | Duzce University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational [Patient Registry] |
Background/aim: Investigators aimed to investigate the effect of D vitamin levels on
Sugammadex and Neostigmine reverse durations in the study.
Materials and methods: Eighty patients between 18 and 65 years, with ASA I-III status who
were undergoing surgery under general anaesthesia were included the study. All patients were
randomly divided into two groups with double blindness and 1.25 (OH) 2 vitamin D, 25 (OH) 2
vitamin D, and calcium levels were measured. At the end of the operation, 2 mg/kg of
Sugammadex was administered to one group and Atropine + Neostigmine to the other group. The
patients were also divided into two groups as to whether their vitamin D levels were ≥ 30
ng/mL or below.
A train of four values was recorded after a hypnotic agent was given at the beginning and
throughout the operation. The time to complete the disappearance of response to TOF
stimulation was recorded as T0.
End of the operation: When 2 responses to TOF stimulation were taken, the following times
were recorded until the extubation phase by administering at least 2 mg/kg of Sugammadex or
0.05 mg/kg of Neostigmine 0.05 mg/kg of Atropine per kg of body weight. The time until the
TOF value reached 50,70,90% and extubation were recorded.
Status | Completed |
Enrollment | 84 |
Est. completion date | March 1, 2018 |
Est. primary completion date | March 1, 2018 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion: - undergoing surgery under general anesthesia - ASA I-III - between the ages of 18 and 65 years old. Exclusion - diabetes - kidney - muscle - hepatic diseases - metabolic diseases |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Duzce University |
Holick MF. Vitamin D status: measurement, interpretation, and clinical application. Ann Epidemiol. 2009 Feb;19(2):73-8. doi: 10.1016/j.annepidem.2007.12.001. Epub 2008 Mar 10. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Reverse times | The time until the TOF value reaches 50,70,90% and extubation were recorded. | 10 minute | |
Secondary | Rocuronium effect unset time | Time to complete disappearance of response to TOF stimulation was recorded as T0 | 4 minute |
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