Familial Clustering of Vitamin D Deficiency Via Shared Environment: The Korean National Health And Nutrition Examination Survey 2008-2012

Vitamin D Deficiency Clinical Trial

Official title:

Familial Clustering of Vitamin D Deficiency Via Shared Environment: The Korean National Health And Nutrition Examination Survey 2008-2012

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03349879
• Other study ID #: 2012-01EXP-01-2C
• Status: Completed
• Phase: N/A
• First received: November 16, 2017
• Last updated: November 21, 2017
• Start date: January 1, 2008
• Est. completion date: December 31, 2012

Study information

• Verified date: November 2017
• Source: Yonsei University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Vitamin D deficiency is a modifiable risk factor for poor bone health. Familial correlation of serum 25-hydroxyvitamin D concentration (25(OH)D) was reported in twin- or family-based studies, mostly from Caucasian parent-offspring pairs. However, data on the familial association of 25(OH)D in extended family structure and the relative contribution of genetic and shared environmental factors on serum 25(OH)D level are limited in Asian populations. In this study, the investigators aimed to assess the relative contribution of additive genetic and environmental components on serum 25(OH)D level by variance components method in a nationwide family-based cohort. Further, the investigators will evaluate the association of vitamin D status of index individual with prevalent vitamin D deficiency of each family member including spouse, offspring, sibling, and grand-offspring. Additive influences of paternal and maternal vitamin D status on offspring will be also investigated.

Description:

From the Korean National Health and Nutritional Examination Survey (KNHANES) conducted between 2008 and 2012, familial correlations for 25(OH)D will be estimated in different types of family relation pairs in 28551 subjects from 10882 families. The relative contribution of additive genetic and shared or individual environmental factors for variance of 25(OH)D level will be calculated using variance component method. Interactions between paternal and maternal vitamin D status for 25(OH)D level of offspring will be evaluated.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 28551
• Est. completion date: December 31, 2012
• Est. primary completion date: December 31, 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 10 Years to 95 Years

Eligibility

Inclusion Criteria:

• KNHANES(Korean National Health and Nutrition Examination Survey) 2008-2012 participants

Exclusion Criteria:

• missing value on 25-hydroxyvitamin D levels

• data on another household member was unavailable

• the precise family relationship between the subjects was unclear

Related Conditions & MeSH terms

• Vitamin D Deficiency

Locations

Country	Name	City	State
Korea, Republic of	Division of Endocrinology, Department of internal Medicine, Yonsei University College of Medicine, Severance Hospital	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Yonsei University

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Vitamin D deficiency	Vitamin D deficiency (serum 25(OH)D < 30 nmol/L)	1 minute after the survey (cross-sectional analysis)