Vitamin D Deficiency Clinical Trial
Official title:
The Effect of Oral Vitamin D Versus Narrow-Band UV-B Exposure on the Lipid Profile
Participants in this study will be randomized to receive either oral vitamin D pills OR ultraviolet light treatment. The investigators will compare how these two methods of raising vitamin D levels will affect cholesterol levels.
Potential subjects will be screened for eligibility, including serum 25(OH)D levels <20ng/ml.
Eligible subjects will be randomly assigned to receive either: 1) oral vitamin D3, 50,000
units weekly for 8 weeks or 2) narrow-band UVB radiation, 2 treatments/wk for 8 weeks.
Duration of treatment will be based on skin type. After 8 weeks, 25(OH)D levels will be
measured monthly. For participants with levels <35 ng/ml, additional doses of oral vitamin D3
or UV radiation will be administered.
A subset of participants from both groups will participate in a skin biopsy cohort, where
skin biopsies are obtained before and after 8 weeks of treatment.
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