Vitamin B 12 Deficiency Clinical Trial
Official title:
Cobalamin Status in Young Children With Gastrointestinal Symptoms or Feeding Problems
During fetal life and infancy, an adequate cobalamin status is important for normal growth
and central nervous system development. During the last years we have detected cobalamin
deficiency in a number of infants admitted to the Pediatric Department with various
symptoms, including neurological symptoms and feeding problems. Cobalamin treatment is given
to the infants with biochemical cobalamin deficiency, and leads to loss of symptoms and in
improved physical condition.
In this study we want to establish the prevalence of cobalamin deficiency in infants with
gastrointestinal symptoms and/or feeding problems. Cobalamin status will be investigated in
all children aged 8 months and younger, admitted to the Pediatric Department with these
symptoms. In a randomised intervention trial we will evaluate the effect of cobalamin
supplementation in children with these symptoms and metabolic evidence of impaired cobalamin
status.
Study hypothesis: Cobalamin treatment given to the infants with biochemical cobalamin
deficiency, will lead to loss of symptoms and in improved physical condition.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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