Clinical Trial Details
— Status: Enrolling by invitation
Administrative data
NCT number |
NCT04520893 |
Other study ID # |
2020-03-010 |
Secondary ID |
|
Status |
Enrolling by invitation |
Phase |
N/A
|
First received |
|
Last updated |
|
Start date |
October 22, 2020 |
Est. completion date |
March 2021 |
Study information
Verified date |
February 2021 |
Source |
Hallym University Kangnam Sacred Heart Hospital |
Contact |
n/a |
Is FDA regulated |
No |
Health authority |
|
Study type |
Interventional
|
Clinical Trial Summary
The investigators compare three ventilation modes; volume controlled ventilation, volume
guaranteed pressure controlled ventilation and volume controlled ventilation with pause
during spine surgery for the elderly patients. The investigators can reveal that how lung
collapse can be reduced by optimizing the inspiratory flow pattern under general anesthesia.
Description:
1. All patients were ventilated by an anaesthesia ventilator (Zeus, Dräger, Lübeck,
Germany) under general anesthesia.
2. Ventilation strategy:
- Pressure controlled ventilation volume guaranteed (PCV-VG) mode or volume control
ventilation (VCV) mode
- tidal volume 6-8 mL/kg (predicted body weight)
- Inspiratory/expiratory (I/E) ratio 1:1.5
- Inspired oxygen concentration (FIO2) 0.5 with air
- 3.0 L/min of inspiratory fresh gas flow
- Positive end-expiratory pressure (PEEP) of 5 cm H2O
- Respiratory rate (RR) of 10 to 14 min-1
3. After prone positioning and hemodynamic condition was stabilized, patients were
ventilated with VCV, PCV-VG mode, VCV with pause following a randomized order,
previously determined for each patient. Before each ventilator setting was started, lung
recruitment maneuvers were performed to set the lungs to a defined baseline status.
- ventilation order : one of the following examples is taken by randomization.
VCV 15 min -- VCV pause 15min -- PCV-VG 15min
VCV 15 min -- PCV-VG 15min -- VCV pause 15min
VCV pause 15min -- VCV 15 min -- PCV-VG 15min
VCV pause 15min -- PCV-VG 15min -- VCV 15 min
PCV-VG 15min -- VCV 15 min -- VCV pause 15min
PCV-VG 15min -- VCV pause 15min -- VCV 15 min