Effect of Patient Position on Arterial, End-tidal and Transcutaneous Carbon Dioxide

Ventilation Perfusion Mismatch Clinical Trial

Official title:

Effect of Patient Position on Arterial, End-tidal and Transcutaneous Carbon Dioxide Partial Pressure in Patients Undergoing Laparoscopic Surgery

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT03508791
• Other study ID #: 201804-1
• Status: Not yet recruiting
• Phase: N/A
• Start date: May 20, 2018
• Est. completion date: April 2019

Study information

• Verified date: April 2018
• Source: SMG-SNU Boramae Medical Center
• Contact: Jin-Young Hwang, MD.Ph.D.
• Phone: 82-2-870-2518
• Email: mistyblue15[@]naver.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Investigators evaluate the effect of patient position (Trendelenburg and reverse Trendelenburg) on arterial, end-tidal and transcutaneous carbon dioxide partial pressure in patients undergoing laparoscopic surgery.

Description:

Investigators evaluate the effect of patient position (Trendelenburg and reverse Trendelenburg) on arterial, end-tidal and transcutaneous carbon dioxide partial pressure in patients undergoing laparoscopic surgery. Arterial carbon dioxide partial pressure is assessed intermittently before, during, and after pneumoperitoneum. End-tidal and transcutaneous carbon dioxide partial pressure are continuously monitored.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 142
• Est. completion date: April 2019
• Est. primary completion date: April 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years and older

Eligibility

Inclusion Criteria:

• adult patients undergoing laparoscopic surgery (expected duration of pneumoperitoneum > 1 hour) in the Trendelenburg or reverse Trendelenburg positions

Exclusion Criteria:

• hemodynamically unstable patients due to decompensated heart failure, sepsis, or symptomatic arrhythmia, etc.

• symptomatic pulmonary disease, chronic obstructive pulmonary disease

Related Conditions & MeSH terms

• Ventilation Perfusion Mismatch

Intervention

Other:
• Arterial carbon dioxide monitoring
Arterial carbon dioxide partial pressure is monitored during the laparoscopic surgery undergoing in the Trendelenburg or reverse Trendelenburg positions.
• End-tidal carbon dioxide monitoring
End-tidal carbon dioxide partial pressure is monitored during the laparoscopic surgery undergoing in the Trendelenburg or reverse Trendelenburg positions.
• Transcutaneous carbon dioxide monitoring
Transcutaneous carbon dioxide partial pressure is monitored during the laparoscopic surgery undergoing in the Trendelenburg or reverse Trendelenburg positions.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
SMG-SNU Boramae Medical Center

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Difference between arterial and end-tidal carbon dioxide pressures	Difference between arterial and end-tidal carbon dioxide partial pressures are calculated. (Arterial carbon dioxide partial pressure minus end-tidal carbon dioxide partial pressure)	baseline before CO2 pneumoperitoneum, every 30 minute during CO2 pneumoperitoneum, and 15 min after deflation of CO2
Secondary	Agreement among arterial, end-tidal, and transcutaneous carbon dioxide partial pressure	Arterial, end-tidal, and transcutaneous carbon dioxide partial pressures are recorded and the agreement among the values is analyzed using the statistical test.	baseline before CO2 pneumoperitoneum, every 30 minute during CO2 pneumoperitoneum, and 15 min after deflation of CO2