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VTE Prevention Following Total Hip and Knee Arthroplasty — EPCATIII  

Venous Thromboembolism Clinical Trial

Official title:
Extended Venous Thromboembolism Prophylaxis Comparing Rivaroxaban and Aspirin to Aspirin Alone Following Total Hip and Knee Arthroplasty (EPCATIII)

Clinical Trial Summary

Consented patients undergoing elective total hip and total knee arthroplasty will be randomized to receive either aspirin alone or aspirin and rivaroxaban for prevention of venous thromboembolism.

Clinical Trial Description

Aspirin and rivaroxaban prevent venous thromboembolism (VTE) via different mechanisms. Aspirin is significantly cheaper than rivaroxaban. Aspirin in combination with rivaroxaban was shown to be safe and efficacious in a non-inferiority trial (EPCATII) when compared to rivaroxaban alone. This study will assess if aspirin alone is non-inferior to rivaroxaban and aspirin in the prevention of venous thromboembolism. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04075240
Study type Interventional
Source Nova Scotia Health Authority
Contact Susan L Pleasance, BScN
Phone 902-719-5203
Email susan.pleasance@nshealth.ca
Status Recruiting
Phase Phase 3
Start date February 4, 2021
Completion date April 2026
View Details
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