Safety of a Diagnostic Strategy With D-Dimer Testing for PE

Status Completed

Clinical Trial Summary

To determine whether D-Dimer testing, using the MDA D-Dimer assay, can be used to simplify the diagnostic process for pulmonary embolism (PE). This will be assessed by performing a cohort study in 1000 patients with suspected PE.

To ascertain if an MDA D-Dimer result of less than 0.75 ug/mL FEU obviates the need for further testing and therapy in patients with suspected PE.

Clinical Trial Description

Prospective cohort study of 1000 patients in which those with a negative D-Dimer result undergo no further testing and are followed for 3 months for venous thromboembolism. Patients with a positive D-Dimer undergo standardized testing. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00182221
Study type	Interventional
Source	McMaster University
Contact
Status	Completed
Phase	Phase 3
Start date	August 2003
Completion date	April 2008

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05347550` - Examining the Benefit of Graduated Compression Stockings in the Prevention of vEnous Thromboembolism in Low-risk Surgical Patients	N/A
Enrolling by invitation	`NCT05794165` - Antithrombin to Improve Thromboprophylaxis and Reduce the Incidence of Trauma-Related Venous Thromboembolism	Phase 2
Completed	`NCT02379806` - The SYMPTOMS - SYstematic Elderly Medical Patients Thromboprophylaxis: Efficacy on Symptomatic OutcoMeS - Study	Phase 3
Recruiting	`NCT03691753` - Safety and Efficacy Study of Fitaya Vena Cava Filter	N/A
Completed	`NCT02197416` - Safety of Dabigatran Etexilate in Blood Clot Prevention in Children	Phase 3
Recruiting	`NCT05378035` - DOAC in Chinese Patients With Atrial Fibrillation
Recruiting	`NCT05171075` - A Study Comparing Abelacimab to Dalteparin in the Treatment of Gastrointestinal/Genitourinary Cancer and Associated VTE	Phase 3
Completed	`NCT01895777` - Open Label Study Comparing Efficacy and Safety of Dabigatran Etexilate to Standard of Care in Paediatric Patients With Venous Thromboembolism (VTE)	Phase 3
Completed	`NCT05897697` - Assessing Women's Preferences for Postpartum Thromboprophylaxis: the Prefer-Postpartum Study
Completed	`NCT04736719` - Replication of the AMPLIFY Anticoagulant Trial in Healthcare Claims Data
Completed	`NCT04735523` - Replication of the RECOVER-II Anticoagulant Trial in Healthcare Claims Data
Completed	`NCT04736420` - Replication of the EINSTEIN-DVT Anticoagulant Trial in Healthcare Claims Data
Completed	`NCT02829957` - RAMBLE - Rivaroxaban vs. Apixaban for Heavy Menstrual Bleeding	Phase 2/Phase 3
Completed	`NCT02746185` - Cancer Associated Thrombosis, a Pilot Treatment Study Using Rivaroxaban	Phase 3
Completed	`NCT02912234` - Effect of Clarithromycin on the Pharmacokinetics of Apixaban in Healthy Participants	Phase 1
Completed	`NCT02334007` - Extended Low-Molecular Weight Heparin VTE Prophylaxis in Thoracic Surgery	Phase 1/Phase 2
Completed	`NCT02223260` - Tolerability , PK/PD and Safety of Dabigatran Etexilate Oral Liquid Formulation in Children < 1 Year of Age	Phase 2
Completed	`NCT02661568` - Description of Patients With Acute Venous Thromboembolism in the UK's Clinical Practice Research Datalink Linked With Hospital Episode Statistics Dataset (CPRD-HES)	N/A
Completed	`NCT01976988` - Prospective Study on Preoperative Versus Postoperative Venous Thromboprophylaxis in Patients Undergoing Major Colorectal Surgery	Phase 3
Completed	`NCT01431456` - Safety of DAbigatran and RIvaroxaban Versus NAdroparin in the Prevention of Venous Thromboembolism After Knee Arthroplasty Surgery	Phase 3