Effects of Melatonin and Oxygen Consumption and Choroidal Blood Flow — MelO2  

Vasospastic Syndrome Clinical Trial

Official title: Effects of Melatonin on Oxygen Consumption and Choroidal Blood Flow in Women With Vasospastic Syndrome in Comparison to Controls

Status Completed

Clinical Trial Summary

Does melatonin affect basal metabolic rate, increase choroidal blood flow and reduce the vasospastic syndrome (VS)?

The main questions are:

Do women with VS exhibit...

• a different basal metabolic rate

• a reduced choroidal blood flow

• a reduced increase of oxygen consumption after intake of ice-water

• a different oxygen consumption after melatonin intake

• a different choroidal blood flow after melatonin intake

• a different oxygen consumption after melatonin intake and after intake of ice-water….?

Clinical Trial Description

Study description:

Melatonin, a natural hormone of the pineal gland exclusively released during the dark phase, exhibits vasodilatatory effects in distal skin regions and reduces core body temperature. This study investigates whether exogenous melatonin (5mg p.o. at 2p.m.) in the afternoon, when no endogenous melatonin is secreted, increases not only distal skin blood flow, but also choroidal blood flow and changes oxygen consumption. Two subject groups were studied, women with vasospastic syndrome (VS) and controls. The main hypothesis is: melatonin normalizes distal vasoconstriction in VS.

Further questions will also be answered:

Does melatonin affect basal metabolic rate, increase choroidal blood flow and reduce the vasospastic syndrome (VS)?

Do women with VS exhibit:

• a different basal metabolic rate

• a reduced choroidal blood flow

• a reduced increase of oxygen consumption after intake of ice-water

• a different oxygen consumption after melatonin intake

• a different choroidal blood flow after melatonin intake

• a different oxygen consumption after melatonin intake and after intake of ice-water....? ;

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Vasospastic Syndrome

• NCT number: NCT00675181
• Study type: Interventional
• Source: University Hospital, Basel, Switzerland
• Status: Completed
• Phase: N/A
• Start date: May 2008
• Completion date: January 2010