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Clinical Trial Summary

This is a randomized, double blind, multicenter study following surgery with extracorporeal circulation to compare blood pressure optimization with vasopressin versus noradrenaline. It is planned to include 840 patients in order to have 420 patients with vasoplegic syndrome. The primary objective of this study is to determine whether the use of vasopressin to maintain blood pressure following cardiac surgery decreases the number of patients with acute renal failure and/or death compared with the usual use of norepinephrine. Participation in the study involves daily follow-up at D1, D2, and D7 of the onset of the syndrome and then follow-up at D30 and D90.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05568160
Study type Interventional
Source Centre Hospitalier Universitaire Dijon
Contact Pierre-Grégoire GUINOT
Phone 0380281309
Email pierre-gregoire.guinot@chu-dijon.fr
Status Recruiting
Phase Phase 3
Start date January 2, 2023
Completion date March 2026

See also
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