Vasoplegic Syndrome Clinical Trial
Official title:
Prospective Randomized Double-blind Study Evaluating the Superiority of VAsopressin Versus NOradrenaline in the Management of Patients at Risk of Kidney Failure Undergoing Cardiac Surgery With Extracorporeal Circulation
This is a randomized, double blind, multicenter study following surgery with extracorporeal circulation to compare blood pressure optimization with vasopressin versus noradrenaline. It is planned to include 840 patients in order to have 420 patients with vasoplegic syndrome. The primary objective of this study is to determine whether the use of vasopressin to maintain blood pressure following cardiac surgery decreases the number of patients with acute renal failure and/or death compared with the usual use of norepinephrine. Participation in the study involves daily follow-up at D1, D2, and D7 of the onset of the syndrome and then follow-up at D30 and D90.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT04440085 -
RaGuS Trial by Postoperative Patients
|
Phase 4 | |
| Completed |
NCT02479529 -
Weaning of Norepinephrine Guided by the Dynamic Arterial Compliance in Cardiac Surgery Post Operative.
|
Phase 3 | |
| Recruiting |
NCT04054999 -
Methylene Blue vs Cyanokit for Intraoperative Vasoplegic Syndrome in Liver Transplant Patients
|
Phase 4 | |
| Completed |
NCT03333278 -
The Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock Trial
|
Phase 2 | |
| Completed |
NCT02675374 -
Hemodynamic Instability Prevented With Polaramine® Infusion Before Extracorporeal Circulation
|
Phase 3 | |
| Completed |
NCT06160219 -
Prophylactic Use of Hydroxycobolamin in Vasoplegic Syndrome in Adult Patients Undergoing Cardiopulmonary Bypass
|
Phase 2/Phase 3 | |
| Completed |
NCT05354193 -
Analysis of miRNAs Expression in Vasoplegic Syndrome After On-pump Coronary Artery Bypass Surgery
|
||
| Terminated |
NCT03735316 -
Vitamin B12a Vasoplegic Syndrome
|
Phase 2 |