Vasoplegia Clinical Trial
Official title:
Differences in Plasma Concentration of RAAS-axis Hormones in Patients Undergoing Cardiac Surgery With or Without Cardiopulmonary Bypass
This study investigates the question of whether there are differences in the plasma concentration of hormones of the RAAS-axis between patients undergoing on-pump cardiac surgery and those receiving off-pump surgery
In patients undergoing cardiac surgery, the occurrence of vasoplegia or vasoplegic shock is a common and sometimes very severe complication. Although there are multiple factors that may affect the incidence and severity of vasoplegia, it remains unclear which role the use of cardiopulmonary bypass may play in the pathogenesis of this complication. The heart normally pumps blood through the lungs where the blood primarily gets oxygenated. However, it is also known that pulmonary blood flow is also essential for the activation of various hormones, some of which are central to the regulation of vascular tension and blood pressure. If the pulmonary circulation is bypassed, as is the case in on-pump cardiac surgery, it is likely that the resulting differential activity of hormones may cause or contribute to the incidence of vasoplegia. This study aims to show whether cardiopulmonary bypass leads to the differential regulation of hormones of the renin-angiotensin-aldosterone-system which could explain why some patients suffer from vasoplegia or vasoplegic shock following such procedures. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05922982 -
Norepinephrine Weaning Guided by the Hypotension Prediction Index in Vasoplegic Shock After Cardiac Surgery
|
N/A | |
| Recruiting |
NCT04812717 -
Prevention of Low Blood Pressure After Cardiac Surgery in Heart Failure Patients With a Filter Called CytoSorb.
|
N/A | |
| Recruiting |
NCT05925348 -
Endotoxinemia and Vasoplegia Following Cardiothoracic Surgery With Cardiopulmonary Bypass (CPB)
|
||
| Withdrawn |
NCT03446599 -
Hemodynamic Effects of Methylene Blue vs Hydroxocobalamin in Patients at Risk of Vasoplegia During Cardiac Surgery
|
Phase 2 | |
| Recruiting |
NCT02965339 -
Evaluation of the Association Between Pre-existing Endothelial Dysfunction and the Onset of Vasoplegia During Cardiac Surgery With Cardiopulmonary Bypass
|
||
| Recruiting |
NCT05058612 -
Midodrine for the Early Liberation of Vasopressor Support in the ICU (LIBERATE Multi-Site)
|
Phase 4 | |
| Not yet recruiting |
NCT04301479 -
Low Dose Corticosteroid Infusion in Vasoplegia After Cardiac Surgery (CORTIVAS-CS)
|
Phase 3 | |
| Recruiting |
NCT03968926 -
Hypotension During Extracorporeal Circulatory Support Indicated for Cardiogenic Shock
|
||
| Recruiting |
NCT04901169 -
Angiotensin II in Liver Transplantation
|
Phase 2/Phase 3 | |
| Completed |
NCT03744702 -
Impact of Ascorbic Acid Treatment on the Development and Treatment of Vasodilation in Cardiac Surgery
|
Early Phase 1 | |
| Not yet recruiting |
NCT02825056 -
Postoperative Hemodynamics Comparison After High Spinal Block With or Without Intrathecal Morphine.
|
Early Phase 1 | |
| Recruiting |
NCT04964492 -
Assessment of the Hemodynamic Effect of Hydroxocabalamin in Refractory Vasodilatory Shock
|
||
| Completed |
NCT03120637 -
Evaluating in Cirrhotics With Refractory Vasoplegia the Effect of Methylene Blue
|
Phase 4 | |
| Completed |
NCT05199493 -
Reducing Acute Kidney Injury Occurence by Administering Angiotensin II
|
Phase 3 | |
| Completed |
NCT05354193 -
Analysis of miRNAs Expression in Vasoplegic Syndrome After On-pump Coronary Artery Bypass Surgery
|