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Vasculitis clinical trials

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NCT ID: NCT00001156 Completed - Multiple Sclerosis Clinical Trials

Assessment of Patients With Multiple Sclerosis (MS)

Start date: January 23, 1976
Phase: N/A
Study type: Observational

Multiple sclerosis (MS) is a disease of the nervous system. The exact cause of MS is unknown, but it is believed to be an autoimmune condition. Autoimmune conditions are diseases that cause the body's immune system and natural defenses to attack healthy cells. In the case of MS, the immune system begins attacking myelin, the cells that make up the sheath covering nerves. Without myelin, nerves are unable to transmit signals effectively and symptoms occur. This study is directed toward a better understanding of the cause of Multiple Sclerosis (MS). Researchers will evaluate patients with a tentative diagnosis of MS or other neurological diseases possibly caused by a immunological reaction. Patients will undergo a series of three MRIs, taken once a month for three months and submit blood samples for immunological studies.

NCT ID: NCT00001155 Completed - Vasculitis Clinical Trials

Treatment of Wegener's Granulomatosis With Cyclophosphamide

Start date: February 1976
Phase: Phase 2
Study type: Interventional

The purpose of this protocol is to continue to treat patients with Wegener's granulomatosis who have already entered the study, and to treat new patients. The investigators will attempt to correlate the clinical response with specific immunosuppressive effects of drug administration. The investigators are accumulating data on the optimal duration and side effects of therapy.