Vascular Stiffness Clinical Trial
Official title:
The Relationship Between Volemic Status as Assessed by Bioimpedance Spectroscopy, Arterial Stiffness and Hemodynamic Instability During Induction of General Anesthesia
NCT number | NCT03237429 |
Other study ID # | GTPopaUMP |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | January 3, 2017 |
Est. completion date | July 1, 2019 |
Arterial hypotension during induction of general anesthesia is a risk factor for developing
postoperative cardiovascular complications. After induction of general anesthesia patients
have a high risk of developing arterial hypotension due to anesthetic drugs who can depress
cardiac contractility and determine vasodilatation. Previous studies have shown that even
short periods of hypotension with a mean arterial pressure of less than 55 mmHg during
surgery is associated with an increased incidence of cardiac injury and acute kidney injury
in the postoperative period.
The volemic status of the patients in the preoperative period is very difficult to quantify
and can vary due to comorbidities of the patient, chronic treatment, preoperative fasting.
Bioimpedance is recognized by over 30 years as a simple and non invasive technique to
determine the volemic status especially in the hemodialysed patients. A new device BCM- Body
Composition Monitoring (Fresenius Medical Care) offers a simple method to determine
extracellular water and total body water. These volumes are determined by measuring impedance
at 50 different frequencies thru electrodes placed at the ankle and wrist. BCM can also
determine lean tissue mass and adipose tissue mass.
Increasing arterial stiffness is the main characteristic of arterial aging; this increase
determines the increase of the afterload, left ventricular hypertrophy, the decrease of
coronary and tissue perfusion. Arterial applanation tonometry is a non-invasive technique
that has been shown to reliably provide indices of arterial stiffness.
In this study investigators wish to determine if there is a correlation between the hidric
status determined by BCM, carotid-femural pulse wave velocity determined with SphygmoCor
system and the development of hypotension during induction of general anesthesia. The
measurements will be obtained before induction of general anesthesia in the pre-surgical
area. During induction of general anesthesia with standard induction agents and Bispectral
index monitoring, brachial blood pressure will be measured by a cuff every minute after the
loss of verbal contact with the patient up to ten minutes after tracheal intubation. A
hypotensive response to anesthesia will be defined as a drop in mean arterial pressure below
55mmHg or a drop in mean arterial pressure with more than 40% than the base line value of the
patient before the surgery.
Measurement of the hidric status and aortic stiffness may represent a valid indicator of the
risk of hypotension during anesthesia induction.
Status | Recruiting |
Enrollment | 150 |
Est. completion date | July 1, 2019 |
Est. primary completion date | March 1, 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - patients scheduled for surgery for a new diagnosed cancer pathology Exclusion Criteria: - diabetes (on insulin therapy), - renal insufficiency (creatinine>2.0mg/dl), - history of arterial bypass, carotid endoarterectomy, - history of atrial fibrillation/flutter, ischemic stroke, transient ischemic attack, myocardial infarction or coronary revascularization (any type) within 6 months, - known left main or 3-vessel coronary disease positive myocardial perfusion study without subsequent revascularization, - heart failure (>3 NYHA) class 3, known left ventricle ejection fraction <30%, pulmonary hypertension (PA systolic >50mmHg), right ventricle dysfunction, - sepsis, - pregnancy, - limb amputation. |
Country | Name | City | State |
---|---|---|---|
Romania | Regional Institute of Oncology, Iasi | Ia?i |
Lead Sponsor | Collaborator |
---|---|
Grigore T. Popa University of Medicine and Pharmacy |
Romania,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Correlation between the hydric status determined by BCM and the development of hypotension during induction of general anesthesia | Correlation between the hydric status determined by BCM and the development of hypotension during induction of general anesthesia | 2 years | |
Primary | Correlation between arterial stiffness and hypotension during induction of general anesthesia | Correlation between the carotid-femural pulse wave velocity determined with SphygmoCor system and the development of hypotension during induction of general anesthesia | 2 years |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03410342 -
The Effects of Types of Fruits and Vegetables on Vascular Function
|
N/A | |
Recruiting |
NCT05424263 -
Acetate and Age-associated Arterial Dysfunction
|
Phase 2 | |
Recruiting |
NCT02564289 -
Cardiovascular Effects of Chronic Snus Use
|
N/A | |
Active, not recruiting |
NCT02863211 -
The Assessment of Large and Small Artery Elasticity for the Early Detection of Cardiovascular Disease
|
||
Completed |
NCT01775865 -
Targeting Inflammation to Treat Cardiovascular Aging
|
Phase 2 | |
Recruiting |
NCT03672760 -
Inspiratory Muscle Training X CardioBreath App Effects On Vagal Modulation And Pulse Wave Velocity
|
N/A | |
Completed |
NCT03929471 -
Target Weight Correction and Vascular Stiffness in Hemodialysis Patients
|
N/A | |
Recruiting |
NCT06117007 -
Effects of Betalains on Cardiovascular Health and Quality of Life
|
N/A | |
Recruiting |
NCT02584439 -
Effect of Pharmacological Heart Rate Reduction on Visco-elastic Properties of the Arterial Wall (BRADYVASC)
|
Phase 3 | |
Terminated |
NCT02273089 -
CPAP to Reduce Arterial Stiffness in Non Sleepy, Moderate to Severe Obstructive Sleep Apnea (STIFFSLEEP)
|
N/A | |
Completed |
NCT01041599 -
Correlation of Albuminuria With Arterial Stiffness
|
N/A | |
Recruiting |
NCT05553223 -
Micro-doses of Physical Activity for COPD
|
N/A | |
Active, not recruiting |
NCT05353790 -
Dietary Exchanges With Avocado and Mango in Pre-diabetes
|
N/A | |
Completed |
NCT06071728 -
Restoring Glycocalyx Thickness in Older Adults to Improve Vascular Function
|
N/A | |
Not yet recruiting |
NCT06419959 -
NightWare and Cardiovascular Health in Veterans With PTSD
|
N/A | |
Recruiting |
NCT03938155 -
Women's Advanced Risk-assessment in Manitoba
|
||
Recruiting |
NCT04817787 -
Exercise Dose and Metformin for Vascular Health in Adults With Metabolic Syndrome
|
Phase 2/Phase 3 | |
Completed |
NCT05701943 -
Comparison of Home- vs. Gym-based Exercise Delivery Modes
|
N/A | |
Not yet recruiting |
NCT05823025 -
Withings Study to Analyze the Accuracy of Pulse Wave Velocity Measurement With Bathroom Scales (WIVOP-Scales)
|
||
Recruiting |
NCT04881292 -
RF Based QIMT & QAS Study on Chinese Adults
|