Vascular Cognitive Impairment Clinical Trial
Official title:
Potential Role of Acupuncture Treatment in Neuronal and Network Dysfunction in Patients With Vascular Cognitive Impairment
Vascular cognitive impairment (VCI) is a broad dimensional term, ranging from mild cognitive
impairment without incapacity on activity of daily living to vascular dementia (VaD),
referred to as significant cognitive impairment and decline in function status.
In this three-year project, we aim to evaluate the effects of biochemical data, early
clinical variables, neuroimaging results, and intervention of acupuncture treatment on
vascular event related cognitive impairment in crossectional analysis and longitudinal
follow-up.
Stroke is a common cerebrovascular disease of the central nervous system leading to serious
medical complication. It results in a high mortality rate and increased disability rate.
Stroke survivors may have long-lasting consequences, including motor dysfunction, sensibility
dysfunction, and cognitive impairment]. Cognition is a key component of rehabilitation and
recovery; therefore it is associated with poor engagement in rehabilitee and outcomes
including increased mortality. As vascular dementia (VaD) is considered the
second-most-common type of dementing illness, accounting for a significant proportion of
total dementia case, vascular cognitive impairment (VCI) is a broader dimensional term,
ranging from mild cognitive impairment without incapacity on activity of daily living to VaD,
referred to as significant cognitive impairment and decline in function status.
Acupuncture is an ancient Chinese medical technique in which fine, stainless steel needles
are inserted into certain anatomical locations of the body surface to elicit neurohormonal
responses of the body system via nerve stimulation. Acupuncture are reported to be probably
effective in improving cognitive function in vascular dementia animal models via multiple
mechanisms such as anti-apoptosis, antioxidative stress reaction, and metabolism enhancing of
glucose and oxygen.
Motor features may not parallel to the cognitive changes, it will serve as the disease
progression marker. Unified Parkinson's Disease Rating Scale (UPDRS)-part III scores and NIH
Stroke Scale (NIHSS) will be used.
1. At Kaohsiung Chang Gung Memorial Hospital, all the patients (n=80) will be included and
receive a Standardized Acupuncture intervention; 40 will be treated with regular
medication; 40 will be treated with acupuncture and regular medication.
2. For acupressure program, all participants are treated in supine position, and a
certified TCM physician applied firm pressure (3 to 5 kg of pressure) with fingertips in
a circular motion at a speed of 2 circles per second for a duration of one minute per
acupoint. The complete process lasts for 8 minutes.
Cognitive function, Motor function, Mood and Sleep will be evaluated at baseline and
follow-up period of time at 3 month, 6 month, and 12 month.
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