Vascular Calcification Clinical Trial
Official title:
Modulation of Vascular Calcification in Chronic Dialysis Patients
50 patients will be randomized and treated with MCO or highflux dialysis for six months (24
weeks) after a run-in phase of 4 weeks Highflux treatment.
Serum samples will be drawn at baseline, after 4, 8 and 24 weeks.
Later, calcifiying vascular smooth muscle cells will be incubated with these serum samples
and calcification will be assessed with Alkaline phosphatase and Alizarin staining.
Primary endpoint:
In vitro Calcification of coronary vascular smooth muscle cells (Alkaline Phosphatase/ WST8)
after six months
Calcifiying vascular smooth muscle cells will be incubated with serum samples obtained after
six months of MCO/HF dialysis and calcification will be assessed with Alkaline phosphatase
and WST8.
Secondary Endpoints:
Aortic Pulse wave velocity after 6 months Calcification propensity after 6 months Physical
activity level after 6 months
Cell culture: Incubation of VSMC with serum samples obtained after 6 months
- Alizarin staining/WST-8
- Measurement of calcification inhibitors Osteopontin and Matrix Gla Protein in
Supernatants
- Apoptosis
The treatment regimen of the patients will not be altered, hence blood flow, dialysate flow
as well as dialysis time will remain constant.
n/a
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