Vancomycin Clinical Trial
Official title:
A Multicentric, Randomised Controlled Clinical Trial to Study the Impact of Bedside Model-informed Precision Dosing of Vancomycin in Critically Ill Children
The overall objective of this project is to investigate the large-scale utility of MIPD of vancomycin at point-of-care in ICU children. This evaluation includes a comparison with the more standard approach on Clinical and patient-oriented measures.
Vancomycin is an antibiotic with a narrow therapeutic-toxic margin. This means that the minimum and maximum target blood target levels differ little from each other. Too low concentrations will reduce the effect of the antibiotic; higher concentrations may result in serious side effects, including renal toxicity. Vancomycin dosing tailored to the critically ill child is challenging. Currently, the starting dose of vancomycin is calculated on a milligram per kilogram basis, which is the same for all patients. The dose is then adjusted based on a measured vancomycin blood concentration (if too high or too low). Despite this measurement, quickly achieving target concentrations remains a major challenge. This multicenter, individual randomized study investigates the added value of a user-friendly computer program for calculating the vancomycin dose in critically ill children, compared to the current standard-of-care. Specifically, the investigators will study whether the use of this computer program leads to a shorter time to reach target concentrations, a reduction in the number and severity of side effects on the kidney, a reduction in patient burden, and a reduction in time to cure and duration of hospitalization. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT03221023 -
Intrawound Vancomycin Prophylaxis for Neural Stimulator
|
Phase 2/Phase 3 | |
Recruiting |
NCT03456544 -
Vancomycin-Associated Acute Kidney Injury: A Cross-Sectional Study From a Multi- Center in China
|
||
Not yet recruiting |
NCT05964114 -
First Time Right of Vancomycin
|
N/A | |
Completed |
NCT02951702 -
Oral Vancomyin for Primary Clostridium Difficile Infection Prophylaxis in Patients Receiving High-Risk Antibiotics
|
Phase 4 | |
Completed |
NCT05535075 -
Model-informed Precision Dosing of Vancomycin in Adults
|
Phase 4 | |
Active, not recruiting |
NCT04911270 -
Clinical Decision Support Tool for Vancomycin Dosing in Children
|
N/A | |
Recruiting |
NCT05823116 -
Continuous vs. Intermittent Infusion Vancomycin
|
Phase 4 | |
Recruiting |
NCT02456974 -
Antibiotic Dosing in Pediatric Intensive Care
|
||
Recruiting |
NCT05257070 -
The Clinical Validation of a Dried Blood Spot Method for Vancomycin and Creatinine
|
||
Enrolling by invitation |
NCT03585426 -
Vancomycin in the Target Site Treatment of Intracranial Infection
|
Phase 4 | |
Completed |
NCT04756895 -
Vancomycin Dose Adjustments Comparing Trough Levels to The AUC/MIC Method Using a Bayesian Approach in a Hospitalized Adult Population
|
N/A | |
Suspended |
NCT02590523 -
Intracameral Antibiotic Safety Study
|
Phase 3 | |
Completed |
NCT03806543 -
The Influencing Factors of Vancomycin Trough Level and the Rate Achieving the Target Trough Level
|
||
Recruiting |
NCT04758442 -
Optimal Dosing of Vancomycin in an Adult Population of Hemato-oncology
|
N/A | |
Completed |
NCT04042233 -
Intraosseous Vancomycin in Primary Total Hip Arthroplasty - Designing a Protocol
|
Phase 4 | |
Recruiting |
NCT02667418 -
Optimal Treatment for Recurrent Clostridium Difficile
|
Phase 4 | |
Recruiting |
NCT06069206 -
Effect of Direct-from-blood Bacterial Testing on Antibiotic Administration and Clinical Outcomes
|
N/A | |
Completed |
NCT03453684 -
Pharmacokinetics of Preoperative Vancomycin
|
Phase 4 | |
Recruiting |
NCT06426836 -
Pediatric Antibiotic Dosing in Extracorporal Membrane Oxygenation (PADECMO)
|
N/A |