The Influencing Factors of Vancomycin Trough Level and the Rate Achieving the Target Trough Level

Vancomycin Clinical Trial

Official title:

The Influencing Factors of Vancomycin Trough Level and the Rate Achieving the Target Trough Level in Critically Ill Patients: A Retrospective Observational Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03806543
• Other study ID #: 2018ZDSYLL117-P01
• Status: Completed
• Start date: January 1, 2015
• Est. completion date: December 31, 2017

Study information

• Verified date: January 2019
• Source: Southeast University, China
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The aim of this study was to assess factors that may influence vancomycin trough level and the rate achieving the target trough level in critically ill patients.

Description:

This retrospective observational study included adult patients treated with intravenous vancomycin in intensive care unit of Zhongda Hospital from January 2015 to December 2017. Vancomycin dose was based on international consensus and adjusted according to estimated glomerular filtration rate (eGFR) calculated by the Cockcroft-Gault equation. vancomycin trough level (VTL) was retained at steady state (after the third dose). Linear regression was performed to determine the correlation between factors prior to the first vancomycin dose and VTL. Distribution of VTL and percentage of patients achieving the target trough level (15-20mg/L) was observed in different renal function.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 165
• Est. completion date: December 31, 2017
• Est. primary completion date: December 31, 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Adult ICU patients (age=18 years) treated with intravenous vancomycin were included

Exclusion Criteria:

• Chronic renal dysfunction and acute renal injury patients treated with Renal Replacement therapy

• VTL was not retained at steady-state

• Vancomycin treatment time=48h

• Vancomycin dose did not meet study definitions

• Palliative care

Related Conditions & MeSH terms

• Vancomycin

Intervention

Drug:
• Vancomycin
adult patients treated with intravenous vancomycin in intensive care unit

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Southeast University, China

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Rate of patients achieving the target vancomycin trough(15-20mg/L)	Vancomycin trough level was retained at steady state (after the third dose). If a patient has multiple measurements of vancomycin trough level, the first measurement is collected.Rate of patients achieving the target trough level (15-20mg/L) was observed.	3 years