Vaginitis Clinical Trial
Official title:
Establishment of a Sensitive System for Analysis of Child-bearing Women Vaginal Microbiota Which Overall Evaluation of Microscopic Precision Reference Standards
The vaginal microbiota is an important biological barrier for host against pathogens or
opportunistic pathogens. Undermining the balance of the vagina is closely related to
infectious diseases and tumors.
The vaginal microbiota of child-bearing women of age is dominated by Lactobacillus species,
including major four species: Lactobacillus crispatus, Lactobacillus jensenii, Lactobacillus
gasseri and Lactobacillus iners, followed by obligate anaerobes such as Gardnerella
vaginalis, Atopobium vaginae, Mobiluncus curtisii, and Prevotella .
Currently, There are almost 99% bacteria can not to be found with bacterial culture. Based
on microscopy and conventional culture method to obtain vaginal microflora information have
a variety of deviation. For this reason, The in-depth study of complex vaginal flora and the
correct understanding of disease faces a serious obstacle. With the development of
High-throughput sequencing technology， metagenomics can get all the composition and
distribution of microorganisms from the sample which traditional knowledge may not be with
microorganism culture method. Therefore, Re-evaluation of existing microflora diagnostic
criteria for clinical diagnosis of the disease is necessary.
In this study, the investigators use high-throughput sequencing technology to detect women
of childbearing age vaginal microflora of metagenomic distribution. Including bacteria,
fungi, viruses, protozoa, and other microorganisms. Based on the study results of
metagenomic, the investigators want to re-cognition the"normal flora"of women of
childbearing age ,and develop vaginal microflora microscopic evaluation of the integrity of
the reference standard.
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