Clinical Trials Logo

Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT05582564
Other study ID # 00001
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date June 2, 2021
Est. completion date January 31, 2022

Study information

Verified date October 2022
Source University of Bari Aldo Moro
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

COVID-19 vaccine hesitancy can be observed at different rates in different countries. 1,068 people were surveyed in France and Italy to inquire about individual potential acceptance, focusing on time preferences, in a risk-return framework: having the vaccination today, in a month, and in 3 months; perceived risks of vaccination and COVID-19; and expected benefit of the vaccine. A randomized controlled trial was conducted to understand how everyday stimuli, such as fact-based news about vaccines, impact on audience acceptance of vaccination. The main experiment involved two groups of participants and two different articles about vaccine-related thrombosis taken from two Italian newspapers. One article used a more abstract description and language, and the other used a more anecdotical description and concrete language; each group read only one of these articles. Two other groups were assigned categorization tasks; one was asked to complete a concrete categorization task and the other an abstract categorization task.


Description:

The goal of this RCT is to learn how journalistic news can affect vaccine hesitancy. 2 cohorts of unvaccinated individual, one Italian, one French. 5 arms design: 1. participants reading a fact-based newspaper article written in an abstract language 2. participants reading a fact-based newspaper article written in a more concrete language 3. participants performing abstract categorization task 4. participants performing concrete categorization task 5. control group answering questionnaire Research questions: i) Does a more abstract vs concrete language increase the willingness to receive the vaccine? ii) Does a more abstract vs concrete mindset increase the willingness to receive the vaccine? iii) Is a gender effect detectable?


Recruitment information / eligibility

Status Completed
Enrollment 1068
Est. completion date January 31, 2022
Est. primary completion date June 20, 2021
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 64 Years
Eligibility Inclusion Criteria: unvaccinated individuals Exclusion Criteria: vaccinated individuals

Study Design


Related Conditions & MeSH terms


Intervention

Other:
abstract vs concrete texts
The main experiment involved two groups of participants and two different articles about vaccine-related thrombosis taken from two Italian newspapers. One article used a more abstract descriptive style and language, while the other used a more anecdotical style and concrete language: each group read only one of these articles. Both articles are the same length and describe an episode of vaccine-related thrombosis. The abstract text uses a more formal and impersonal language, reporting more scientific considerations; the concrete text uses a more familiar and emotional style and provides a more anecdotical description of the case. Texts were also weighted according to a concreteness semantic vocabulary. French received translated versions.Two other groups were assigned categorization tasks; one was asked to complete a concrete categorization task and the other an abstract categorization task.

Locations

Country Name City State
Italy University of Bari Aldo Moro Bari

Sponsors (1)

Lead Sponsor Collaborator
University of Bari Aldo Moro

Country where clinical trial is conducted

Italy, 

References & Publications (4)

Liberman N, Trope Y. Traversing psychological distance. Trends Cogn Sci. 2014 Jul;18(7):364-9. doi: 10.1016/j.tics.2014.03.001. Epub 2014 Apr 10. Review. — View Citation

Loomba S, de Figueiredo A, Piatek SJ, de Graaf K, Larson HJ. Measuring the impact of COVID-19 vaccine misinformation on vaccination intent in the UK and USA. Nat Hum Behav. 2021 Mar;5(3):337-348. doi: 10.1038/s41562-021-01056-1. Epub 2021 Feb 5. Erratum in: Nat Hum Behav. 2021 Mar 8;:. Nat Hum Behav. 2021 Jul;5(7):960. — View Citation

MacDonald NE; SAGE Working Group on Vaccine Hesitancy. Vaccine hesitancy: Definition, scope and determinants. Vaccine. 2015 Aug 14;33(34):4161-4. doi: 10.1016/j.vaccine.2015.04.036. Epub 2015 Apr 17. — View Citation

Trope Y, Liberman N. Temporal construal. Psychol Rev. 2003 Jul;110(3):403-21. Review. — View Citation

Outcome

Type Measure Description Time frame Safety issue
Primary vaccine hesitancy; number of participants accepting the vaccination revealed preferences same day
See also
  Status Clinical Trial Phase
Completed NCT05994820 - Chatbot-based Intervention to Promote Vaccine Acceptance in Varansi, India N/A
Completed NCT05537441 - Precision Vaccine Promotion in Underserved Populations N/A
Recruiting NCT05998824 - COVID-19 Vaccination Hesitancy in Adults With Sickle Cell Disease N/A
Terminated NCT05167422 - Trusted Messenger Intervention N/A
Completed NCT04939506 - COVID-19 Vaccine Education at the Point of Testing to Increase Vaccine Uptake in Vulnerable Communities in SE Louisiana N/A
Recruiting NCT05787015 - Testing a Personalized Normative Feedback Intervention for Vaccine Hesitancy N/A
Enrolling by invitation NCT06062056 - Motivational Interviewing for Vaccine Uptake in Latinx Adults N/A
Recruiting NCT05473936 - A CHW Intervention to Identify and Decrease Barriers to COVID 19 Testing & Vaccination N/A
Not yet recruiting NCT05531058 - The Impact of a Web-based Psychoeducation Programme With a Motivational AI Chatbot on Covid-19 Vaccine Hesitancy N/A
Not yet recruiting NCT05120817 - Emphasizing the Personal Versus the Social in Educational Interventions For Decreasing Vaccine Hesitancy N/A
Completed NCT05206669 - Testing Messages to Promote HPV Vaccination N/A
Completed NCT06155877 - Testing The Effectiveness Of Two Interventions To Reduce Vaccine Hesitancy Among Adolescents N/A
Completed NCT06124131 - Building Engagement Using Financial Incentives Trial - Colorectal Cancer Screening N/A
Recruiting NCT06417762 - Dime La VerDAD: Verify, Debunk, and Disseminate N/A
Recruiting NCT06297876 - COVIDVaxStories: Randomized Trial to Reduce COVID-19 Vaccine Hesitancy in Populations of Color N/A
Enrolling by invitation NCT06156228 - Multilevel Intervention of COVID-19 Vaccine Uptake Among Latinos N/A
Recruiting NCT05042011 - Role of mHealth-based Interventions Including Social Media to Improve Childhood Immunization Coverage During COVID 19 Pandemic in Pakistan: Qualitative Study
Not yet recruiting NCT06374134 - The Impact of Community and Patient Engagement Practices on Vaccine Confidence in the United States
Completed NCT01385501 - Educational Intervention to Improve Vaccine Acceptance N/A
Completed NCT05390697 - Educational Videos to Address Vaccine Hesitancy in Childhood Immunization N/A