Clinical Trials Logo

Clinical Trial Summary

Leiomyomas are the most common benign neoplasms of women's reproductive system affecting 20-30% of women within the reproductive ages. Sestrins are serum proteins which are highly expressed under circumstances of DNA damage, hypoxia and oxditive stress and play an important role in autophagia. The aim of this study is to evaluate the relationship of serum sestrin proteins with development of leiomyomas.


Clinical Trial Description

Leiomyomas are the benign neoplasms of uterus and the role of genetics, estrogen levels and obesity has already been shown in their development. Higher levels of serum sestrin proteins have already been associated with DNA damage, hypoxia and oxidative stress and sestrin plays an important role in autophagia. In order to evaluate the role of serum sestrin in the development of leiomyomas 30 patients between 18-45 years of age who were diagnosed with uterine leiomyomas with transvaginal ultrasonography will be included in the study group. Their serum sestrin levels will be determined and compared with that of 30 healthy subjects recruited during the same study period at the same clinic. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04819633
Study type Observational
Source Sisli Hamidiye Etfal Training and Research Hospital
Contact
Status Completed
Phase
Start date January 1, 2021
Completion date April 1, 2021

See also
  Status Clinical Trial Phase
Recruiting NCT04519593 - ABSOLUTELY: A Temporary Uterine Blood Supply Occlusion for Laparoscopic Myomectomy in Patients With UTErine LeiomYoma N/A
Not yet recruiting NCT03219385 - Directed Ablation of Uterine Fibroids Using a Noninvasive Approach N/A
Completed NCT01338831 - Phase I Study of LFA102 in Patients With Prolactin Receptor-positive Castration-resistant Prostate Cancer or Prolactin Receptor-positive Metastatic Breast Cancer Phase 1
Completed NCT01468402 - Predictive Factors of Pelvic Magnetic Resonance in the Response of Arterial Embolization of Uterine Leiomyoma N/A
Completed NCT03847077 - Trial of a Patient Education Tool For Leiomyoma N/A
Completed NCT00365989 - MR Guided Focused Ultrasound Treatment of Uterine Fibroids With Enhanced Sonication Phase 3
Completed NCT03751124 - Study of Relugolix With Estradiol and Norethindrone Acetate in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids Phase 3
Recruiting NCT02495311 - The Association Between Adenomyosis/Uterine Myoma and Lower Urinary Tract Symptoms
Completed NCT00332033 - Development of a Non-Invasive Treatment for Uterine Leiomyoma (Fibroids) Phase 2
Completed NCT04874246 - Comparison of Concentration of Vasopressin During Robot-assisted Laparoscopic Myomectomy N/A
Not yet recruiting NCT04282863 - Comparison Between Robotic (RM) and Laparoscopic Myomectomy (LM) N/A
Recruiting NCT06115408 - Evaluation of Using Dienogest and N-Acetyl Cysteine on the Volume of Uterine Leiomyoma Phase 2/Phase 3
Completed NCT02049242 - Uterine Tourniquet at Open Myomectomy N/A
Completed NCT02059954 - Vaginal vs. Laparoscopic Hysterectomy N/A
Terminated NCT01738724 - Study of the Efficacy of Dienogest in the Treatment of Uterine Leiomyomas When Compared to Desogestrel and Goserelin Phase 4
Terminated NCT01280045 - Influence of Aromatase Inhibitors and GnRH Analogs to Treat Uterine Leiomyoma by Vaginal Hysterectomy N/A
Withdrawn NCT02736435 - Treatment of Uterine Fibroids With Magnetic Resonance Guided High Intensity Focused Ultrasound Phase 3
Completed NCT00341848 - Postpartum Uterine Regression
Completed NCT01715597 - Study on the Effect of Intravenous Ascorbic Acid on Intraoperative Blood Loss in Women With Uterine Myoma Phase 3
Completed NCT03328260 - High Intensity Focused Ultrasound in Uterine Myoma N/A