Evaluating Serum Sestrin in Leiomyoma Patients

Status Completed

Clinical Trial Summary

Leiomyomas are the most common benign neoplasms of women's reproductive system affecting 20-30% of women within the reproductive ages. Sestrins are serum proteins which are highly expressed under circumstances of DNA damage, hypoxia and oxditive stress and play an important role in autophagia. The aim of this study is to evaluate the relationship of serum sestrin proteins with development of leiomyomas.

Clinical Trial Description

Leiomyomas are the benign neoplasms of uterus and the role of genetics, estrogen levels and obesity has already been shown in their development. Higher levels of serum sestrin proteins have already been associated with DNA damage, hypoxia and oxidative stress and sestrin plays an important role in autophagia. In order to evaluate the role of serum sestrin in the development of leiomyomas 30 patients between 18-45 years of age who were diagnosed with uterine leiomyomas with transvaginal ultrasonography will be included in the study group. Their serum sestrin levels will be determined and compared with that of 30 healthy subjects recruited during the same study period at the same clinic. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04819633
Study type	Observational
Source	Sisli Hamidiye Etfal Training and Research Hospital
Contact
Status	Completed
Phase
Start date	January 1, 2021
Completion date	April 1, 2021

View Details

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