Urothelial Carcinoma Clinical Trial
Official title:
Vasculogenic Mimicry in Urothelial Carcinoma and Its Association With Clinicopathologic Features
In this study, the investigators aim at:
1. Evaluate the presence of vasculogenic mimicry in urothelial carcinomas by CD31-PAS
double staining.
2. Correlate the presence of vasculogenic mimicry with the clinicopathologic features as
age, sex, TNM stage, pathological grade, recurrence, carcinoma in situ, lymphovascular
emboli, lymph node metastasis, necrosis, surgical margin, multifocality and tumor size
in urothelial carcinoma.
Bladder cancer is the ninth most common cancer worldwide which seriously affects human
health. In Egypt, it is the third common malignant tumor.
Urothelial carcinoma (UC) is considered the most common histologic type of bladder cancer.
It is well recognized that the biological behavior of several cancers is closely related to
their blood supply. Tumor progression and metastasis have been long associated with tumor
angiogenesis. However, several studies demonstrated that vascular targeting drugs which
induce endothelial cell apoptosis have a little effect. So, it has been suggested that novel
tumor microcirculation patterns may exist in these neoplasms.
Vasculogenic mimicry (VM), is a novel tumor microcirculation system. Maniotis et al initially
discovered VM in melanoma and defined these channels to be composed of tumor basement
membrane lined externally by tumor cells, lacking blood vessel endothelium and containing
plasma and red blood cells. So VM can be distinguished using immunohistochemical (IHC)
staining and histochemical double staining. VM is CD31- or CD34-negative (endothelial
markers) and periodic acid-Schiff (PAS) positive.
Vasculogenic mimicry was detected in several malignant tumors. Several studies reported that
VM can promote tumor progression and metastasis and it is positively associated with
pathological grade, stage, recurrence and drug resistance. Previous studies which evaluate,
the role of VM in urothelial carcinoma yield controversial results. So, the value of VM in
urothelial carcinomas and its relation to the clinicopathologic parameters remains to be
elucidated.
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