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Avelumab in Combination With AVB-S6-500 in Patients With Advanced Urothelial Carcinoma — COAXIN  

Urothelial Carcinoma Clinical Trial

Official title:
Phase I Study of Avelumab in Combination With AXL Inhibitor AVB-S6-500 in Patients With Advanced Urothelial Carcinoma

Clinical Trial Summary

The purpose of this research study is to test the safety of avelumab and AVB-S6-500 and see what effects (good and bad) this combination treatment has on patients with advanced urothelial carcinoma.

Clinical Trial Description

Patients will have tests and exams to see if they are eligible for the clinical trial. If found eligible, the patient will receive treatment with avelumab and AVB-S6-500 by vein once every two weeks. This study has two parts in order to determine the maximum tolerated dose of AVB-S6-500. If the patient is enrolled on the first dose level, the patient will be treated at a higher dose every two weeks with AVB-S6-500. If the patient is enrolled on the second dose level, the patient will be receive AVB-S6-500 only once a week at a lower dose. The patient would continue to receive avelumab twice weekly at the same dose. Patients will receive the study treatment as long as there is evidence that the tumor is not growing or spreading and they are not having any unacceptable, bad side effects. Patients will be monitored during treatment with tests and exams and after treatment completion for up to one year. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04004442
Study type Interventional
Source University of Oklahoma
Contact
Status Active, not recruiting
Phase Phase 1
Start date February 17, 2020
Completion date September 2024
View Details
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