Atezolizumab With or Without Bevacizumab in Cisplatin-ineligible Patients

Status Active, not recruiting

Clinical Trial Summary

This is a randomized phase II study assessing the activity of bevacizumab combined with atezolizumab compared to atezolizumab alone in metastatic urothelial carcinoma subjects who are ineligible for cisplatin-based therapy. Eligible subjects will be randomized to receive treatment with either (Arm A) atezolizumab 1200 mg (flat dose) IV plus bevacizumab 15 mg/kg IV every 21 days versus (Arm B) atezolizumab 1200 mg (flat dose) IV monotherapy every 21 days. Cross-sectional imaging will be performed every 9 weeks on therapy for the first 12 months and then every 12 weeks thereafter to assess for response.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03133390
Study type	Interventional
Source	New York University School of Medicine
Contact
Status	Active, not recruiting
Phase	Phase 2
Start date	September 1, 2017
Completion date	January 2020

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