Urothelial Carcinoma Clinical Trial
Official title:
Level of DNA Methylation in People With Urothelial Carcinoma
| NCT number | NCT01378052 |
| Other study ID # | DMR100-IRB-092 |
| Secondary ID | |
| Status | Recruiting |
| Phase | N/A |
| First received | June 20, 2011 |
| Last updated | June 21, 2011 |
| Start date | June 2011 |
Many studies previously showed the significant association between urinary arsenic profiles and urothelial carcinoma (UC) risk and observed the increased UC risk in people with lower plasma folate and higher homocysteine than those with higher plasma folate and lower homocysteine. The investigators would expect to explore the interactions among global DNA methylation, one-carbon metabolic pathway factors, urinary arsenic profiles and UC.
| Status | Recruiting |
| Enrollment | 200 |
| Est. completion date | |
| Est. primary completion date | June 2012 |
| Accepts healthy volunteers | Accepts Healthy Volunteers |
| Gender | Both |
| Age group | 21 Years and older |
| Eligibility |
Inclusion Criteria: - Clinical diagnosis of urothelial carcinoma - The voluntary of participating the study Exclusion Criteria: - Age smaller than 20 years - Pregnant women - Not willing to participate the study because of their personal reasons |
Observational Model: Case Control, Time Perspective: Retrospective
| Country | Name | City | State |
|---|---|---|---|
| Taiwan | Department of Urology, China Medical University Hospital | Taichung | 404 |
| Lead Sponsor | Collaborator |
|---|---|
| China Medical University Hospital |
Taiwan,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | urothelial carcinoma | Pathological verification of UC was done by routine urological practice including endoscopic biopsy or surgical resection of urinary tract tumors followed by histopathological examination by board-certified pathologists. | one year | No |
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