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NCT00662064 Clinical Trial

Pharmacology and Physiology of the Lower Urinary Tract

Urologic Diseases Clinical Trial

Official title:
Pharmacology and Physiology of the Lower Urinary Tract

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT00662064
Other study ID # 00/0039
Secondary ID
Status Recruiting
Phase N/A
First received April 16, 2008
Last updated June 19, 2008
Start date February 2002
Est. completion date December 2008

Study information
Verified date June 2008
Source University College London Hospitals
Contact Thomas M Kessler, MD
Phone 44-207-829-8713
Email tkessler@gmx.ch
Is FDA regulated No
Health authority United Kingdom: National Health Service
Study type Observational

Clinical Trial Summary

The function of the lower urinary tract is simple - urine storage and voiding. However, despite this simplicity of function, the control of the lower urinary tract is a rather complex, multilevel process (urothelium, detrusor, peripheral nerves, spinal cord and higher cerebral centres) and the mechanisms involved remain poorly elucidated.

This study is designed to gain a more in depth understanding of the lower urinary tract function. Using bladder biopsies, tissue staining for characteristic markers present on nerves and other cells will be performed. We hypothesize that certain markers are altered in disease and turn back towards the control level of healthy people or patients with successful medical treatment.

Recruitment information / eligibility
Status Recruiting
Enrollment 200
Est. completion date December 2008
Est. primary completion date December 2008
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 18 Years and older
Eligibility Inclusion Criteria:

- Patients with lower urinary tract dysfunction

- Controls with normal lower urinary tract function

Exclusion Criteria:

- Age < 18 years old

- Pregnancy

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
United Kingdom Department of Uro-Neurology, The National Hospital for Neurology and Neurosurgery London

Sponsors (1)
Lead Sponsor Collaborator
University College London Hospitals

Country where clinical trial is conducted

United Kingdom, 

Outcome
Type Measure Description Time frame Safety issue
Primary Immunohistochemistry + PCR of bladder tissue not specified (storage of biopsies) No
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