The Effect of Perioperative Lidocaine Infusion on Neutrophil Extracellular Trapping

Urologic Cancer Clinical Trial

Official title:

The Effect of Perioperative Lidocaine Infusion on Neutrophil Extracellular Trapping in the Patients Undergoing the Robot-assisted Prostatectomy

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT04840511
• Other study ID #: NETosis-prostate Ca
• Status: Active, not recruiting
• Phase: N/A
• Start date: September 27, 2021
• Est. completion date: April 30, 2027

Study information

• Verified date: January 2023
• Source: The Catholic University of Korea
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study will be done to investigate perioperative lidocaine infusion on neutrophil extracellular trapping in the patients undergoing the robot-assisted prostatectomy.

Description:

Neutrophil extracellular trapping by analyzing the meyloperoxidase, neutrophil elastase, citrullinated histone3

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 60
• Est. completion date: April 30, 2027
• Est. primary completion date: April 30, 2022
• Accepts healthy volunteers: No
• Gender: Male
• Age group: 20 Years to 75 Years

Eligibility

Inclusion Criteria:

• patients scheduled robot-assisted prostatectomy

Exclusion Criteria:

• lidocaine allergy Hx

• hemodynamic unstable patients

• weight < 40kg

• arrhythmia or bradycardia

Related Conditions & MeSH terms

• Urologic Cancer
• Urologic Neoplasms

Intervention

Drug:
• lidocaine group
lidocaine 1.5 mg/kg bolus (infused over 10 min) followed by 2.0 mg/kg/h during operation and 1.0 mg/kg/h during postoperative 24 hours (no more than 120 mg/h)
• control group
normal saline 0.15 ml bolus followed by 0.2 ml/kg/hr during operation and 0.1 ml/kg/hr during postoperative 24 hours

Locations

Country	Name	City	State
Korea, Republic of	Seoul St.Mary's Hospital	Seoul	Seocho-gu

Sponsors (1)

Lead Sponsor	Collaborator
The Catholic University of Korea

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	the severity of postoperative pain using NRS	This will be measured using NRS (numeric rating scale; 0=no pain, 10=the worst pain)	during postoperative 24 hours
Primary	Concentration of citrullinated histone3	This will be obtained using ELISA.	24 hours after surgery
Secondary	Concentration of meyloperoxidase	This will be obtained using ELISA.	24 hours after surgery
Secondary	Concentration of neutrophil elastase	This will be obtained using ELISA.	24 hours after surgery