Tamsulosin as Adjuvant Treatment Prior to Endoscopic Ureterolithotomy

Status Terminated

Clinical Trial Summary

This a study aiming to compare treatment with tamsulosin versus placebo in patients undergoing endoscopic treatment for urolithiasis. The main outcome is the rate of stone free patients.

Clinical Trial Description

Endoscopic treatment of urolithiasis has increased during the last several years. Adrenergic receptors have been described mainly in the distal ureter. Blockage of adrenergic receptors has been associated to a decrease in ureteral resistance. In this study the investigators hypothesized that alpha blockers are associated to a decrease in ureteral resistance with an increase in successful endoscopic management of urolithiasis.

Only patients with urolithiasis undergoing to endoscopic treatment are offered to participate. Patients are randomized between placebo arm or tamsulosin 0.4 mg/day. Demographic characteristics, stones characteristics and information related to surgery are recorded. Main study outcome is stone free rate and successful insertion of semirigid ureteroscope 8,0 - 9,8 Fr. All patients are follow-up for 30 days after surgery. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03614052
Study type	Interventional
Source	Pontificia Universidad Catolica de Chile
Contact
Status	Terminated
Phase	Phase 4
Start date	June 1, 2018
Completion date	January 26, 2020

View Details

See also
Status	Clinical Trial	Phase
Enrolling by invitation	`NCT04746378` - PRedictive Accuracy of Initial Stone Burden Evaluation.
Recruiting	`NCT05100017` - Methocarbamol vs Oxybutynin for Management of Pain and Discomfort S/P Ureteroscopy Procedure	N/A
Recruiting	`NCT04021381` - Citrate Salts for Stone-free Result After Flexible Ureterorenoscopy for Inferior Calyx Calculi	Phase 3
Completed	`NCT02266381` - A Prospective Comparison of Fluoroscopic, Sonographic or Combined Approach for Renal Access in Percutaneous Nephrolithotomy	N/A
Completed	`NCT01451931` - Study of Tomography of Nephrolithiasis Evaluation	Phase 4
Terminated	`NCT01431378` - Pilot Study of Model Based Iterative Reconstruction Using 64-Slice	N/A
Completed	`NCT02895711` - Radiation Dose of Pediatric Patients During Ureteroscopy
Completed	`NCT01295879` - Vitamin D Repletion in Stone Formers With Hypercalciuria	Phase 4
Completed	`NCT05340075` - Staged Bilateral Percutaneous Nephrolithotomy
Recruiting	`NCT03919227` - Measurement of Resistance During UAS Insertion Procedure in RIRS	N/A
Recruiting	`NCT03717285` - Under Direct Vision vs Under Non Direct Vision of Insertion of UAS in RIRS	N/A
Completed	`NCT05340088` - Optimal Passive Dilation Time in Retrograde Intrarenal Surgery
Completed	`NCT05032287` - Medical Expulsive Therapy Post-SWL For Renal Stones	N/A
Recruiting	`NCT05701098` - SOUND Pivotal Trial - (Sonomotion stOne comminUtion resoNance ultrasounD)	N/A
Not yet recruiting	`NCT04080973` - Metabolic Workup in Patients Suffering From Kidney Stone Disease and Osteopenia	N/A
Terminated	`NCT01736358` - The Use of Intranasal Ketoralac for Pain Management (Sprix)	Phase 4
Completed	`NCT01792765` - Management of Ureteral Calculi Using Ultrasound Guidance: A Radiation Free Approach	N/A
Completed	`NCT06211842` - Genetic Variations That Increase the Risk for Calcium Kidney Stones: a Family-based Study
Not yet recruiting	`NCT02214836` - Ultrasound Imaging of Kidney Stones and Lithotripsy	N/A
Not yet recruiting	`NCT04606758` - Fluoroscopic Guided vs US-guided Percutaneous Nephrolithotripsy for the Treatment of Stone Disease	N/A