Urolithiasis Clinical Trial
Official title:
Prospective Randomized Placebo Controlled Blinded Study to Evaluate the Efficacy of Alfuzosin (Alpha Blocker) on the Success Rates Following SWL.
In latest literature more evidence is available about the positive effect of alpha blocker on stone expulsion from the ureter. Patients benefit from less pain and shortening time to stone expulsion. Our study is design to evaluate whether alfuzosin improves the stone free out come following SWL.
All patients undergoing SWL are included in study. Exclusion criteria: Patient with
radio-lucent stone, patients treated with calcium channel blockers, alpha blockers,
steroids, patients with contraindication to alpha blocker treatment, postural hypotension
patents with abnormal liver function tests.
Patient will be recruited to the study prospectively. Following signature on inform consent
patients will be randomized into 2 groups. One group will be treated with alfuzosin 10mg a
day and the control group with placebo. Treatment will be initiated following the
lithotripsy treatment.
Parameters for investigation includes: demographic and personal data, stone size and
location (obtained by CT or KUB), pain control medication and visual analogue scale
assessment of pain, side effects, clinical squeals, stone free out come. Follow up
evaluation will be at 1 week, 1 month, and 3 months post treatment. Success will be defined
following CT evaluation at 3 months. Treatment ends at stone free achievement or at 3
months.
Endpoints:Stone free rate, time to stone free, side effect.
;
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Enrolling by invitation |
NCT04746378 -
PRedictive Accuracy of Initial Stone Burden Evaluation.
|
||
| Recruiting |
NCT05100017 -
Methocarbamol vs Oxybutynin for Management of Pain and Discomfort S/P Ureteroscopy Procedure
|
N/A | |
| Recruiting |
NCT04021381 -
Citrate Salts for Stone-free Result After Flexible Ureterorenoscopy for Inferior Calyx Calculi
|
Phase 3 | |
| Completed |
NCT02266381 -
A Prospective Comparison of Fluoroscopic, Sonographic or Combined Approach for Renal Access in Percutaneous Nephrolithotomy
|
N/A | |
| Terminated |
NCT01431378 -
Pilot Study of Model Based Iterative Reconstruction Using 64-Slice
|
N/A | |
| Completed |
NCT01451931 -
Study of Tomography of Nephrolithiasis Evaluation
|
Phase 4 | |
| Completed |
NCT02895711 -
Radiation Dose of Pediatric Patients During Ureteroscopy
|
||
| Completed |
NCT01295879 -
Vitamin D Repletion in Stone Formers With Hypercalciuria
|
Phase 4 | |
| Completed |
NCT05340075 -
Staged Bilateral Percutaneous Nephrolithotomy
|
||
| Recruiting |
NCT03919227 -
Measurement of Resistance During UAS Insertion Procedure in RIRS
|
N/A | |
| Recruiting |
NCT03717285 -
Under Direct Vision vs Under Non Direct Vision of Insertion of UAS in RIRS
|
N/A | |
| Completed |
NCT05340088 -
Optimal Passive Dilation Time in Retrograde Intrarenal Surgery
|
||
| Completed |
NCT05032287 -
Medical Expulsive Therapy Post-SWL For Renal Stones
|
N/A | |
| Recruiting |
NCT05701098 -
SOUND Pivotal Trial - (Sonomotion stOne comminUtion resoNance ultrasounD)
|
N/A | |
| Not yet recruiting |
NCT04080973 -
Metabolic Workup in Patients Suffering From Kidney Stone Disease and Osteopenia
|
N/A | |
| Terminated |
NCT01736358 -
The Use of Intranasal Ketoralac for Pain Management (Sprix)
|
Phase 4 | |
| Completed |
NCT01792765 -
Management of Ureteral Calculi Using Ultrasound Guidance: A Radiation Free Approach
|
N/A | |
| Completed |
NCT06211842 -
Genetic Variations That Increase the Risk for Calcium Kidney Stones: a Family-based Study
|
||
| Not yet recruiting |
NCT02214836 -
Ultrasound Imaging of Kidney Stones and Lithotripsy
|
N/A | |
| Not yet recruiting |
NCT04606758 -
Fluoroscopic Guided vs US-guided Percutaneous Nephrolithotripsy for the Treatment of Stone Disease
|
N/A |