Urogynaecology Clinical Trial
Official title:
An Observational Study of the Effect of Antibiotics on the Microbiology of the Bladder in Patients With Overactive Bladder
Verified date | October 2016 |
Source | Medway NHS Foundation Trust |
Contact | n/a |
Is FDA regulated | No |
Health authority | United Kingdom: National Health Service |
Study type | Observational |
The concept of organisms living on or in the human body without causing overt signs of an infection is common in medicine and has been termed a microbiome. Urine from patients with Overactive bladder (OAB) grows different organisms from controls without OAB. However, it is not known if the bacteria that have been identified are innocent commensals or pathogenic organism responsible for the symptoms of OAB. Previous data suggests that treatment with antibiotics does lead to an improvement in overactive bladder symptoms in a large number of patients. On this basis the investigators now treat are patients with similar antibiotic regimes. If antibiotics improve symptoms it would be expected that they would return the microbiome back to how it is in patients without OAB. This study aims to identify the effects of antibiotics on the urinary microbiome and to identify/confirm if antibiotic treatments cause improvement in OAB.
Status | Completed |
Enrollment | 25 |
Est. completion date | October 2016 |
Est. primary completion date | September 2016 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 18 Years to 100 Years |
Eligibility |
Inclusion Criteria: 1. > age 18 years 2. Negative urine dipstick (nitrites) and culture (x10 to the power 5 colony forming units) x105 cfu 3. Idiopathic overactive bladder as per International Continence Society definition Exclusion Criteria: 1. Patients treated with antibiotics for any infection within the last 6 weeks. 2. Patients with known multiple sclerosis, stroke, spinal injury, or other neurological disease 3. Urinary tract infection diagnosed by nitrite positivity or positive urine culture (x105 cfu) 4. Undiagnosed macroscopic or persistent microscopic haematuria needing investigation 5. Previous or current cancer of the urogenital tract. 6. Contraindication to multiple antibiotics 7. No suitable oral antibiotic regime 8. Patients unable to understand the study or complete the questionnaires. |
Observational Model: Cohort, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
United Kingdom | Medway Hospital | Gillingham | Kent |
Lead Sponsor | Collaborator |
---|---|
Medway NHS Foundation Trust |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in bladder microbiology in patients treated with antibiotics. | The number and type of different organisms will be quantified and compared to the pre treatment organisms | 6 weeks | No |
Secondary | Change in the overactive bladder questionnaire (OAB-q) before and after treatment | questionnaire | 6 weeks | No |
Secondary | Change in Patient Perception of Bladder Condition (PPBC) | questionnaire | 6 weeks | No |
Secondary | To identify adherence to the treatment regime | Patients will be asked to identify if they took all of the antibiotics; 75% of the time; 50 or 25% | 6 weeks | No |
Secondary | To identify adverse effects of the treatment | Patients will be asked report side effects of antibiotic treatment | 6 weeks | No |
Secondary | Changes in symptoms using (change from baseline to assessment) | Measured by the International consultation on Incontinence female lower urinary tract syptome questionnaire. (ICI FLUTs) | 6 weeks | No |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT06143072 -
CArE for OAsI Study: Care Pathways and Anorectal Evaluation for OASI Associated Incontinence
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