Interactions Between Cranberry Juice and Antibiotics Used to Treat Urinary Tract Infections

Urinary Tract Infections Clinical Trial

Official title:

Cranberry: Interactions With Anti-Infectious Agents

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00084201
• Other study ID #: R21AT002077-01
• Status: Completed
• Phase: N/A
• First received: June 8, 2004
• Last updated: November 28, 2006
• Start date: July 2006
• Est. completion date: June 2007

Study information

• Verified date: November 2006
• Source: National Center for Complementary and Integrative Health (NCCIH)
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Interventional

Clinical Trial Summary

The purpose of study is to determine whether cranberry juice interacts with antibiotics used to treat urinary tract infections (UTIs).

Description:

Although evidence of its effectiveness is limited, cranberry juice is widely used to prevent urinary tract infections (UTIs). However, recent studies have shown that cranberry juice may affect the way the body absorbs and metabolizes antibiotics used to treat UTIs. This study will determine whether concurrent cranberry juice administration lowers the urinary concentrations of two commonly used antibiotics, amoxicillin and cefaclor.

This study will involve children being treated for UTIs and adults without UTIs. All of the children will continue their prescribed amoxicillin/cefaclor treatment. After 7 to 10 days of antibiotic treatment, the children will be assigned to receive either cranberry juice for 2 days or no additional treatment. Urine samples will be collected from all child participants before and after the administration of cranberry juice to examine the excretion of the antibiotics.

Adult participants will receive two different doses of amoxicillin, with or without cranberry juice. Blood and urine samples will be collected to evaluate the effect of cranberry juice on the absorption and elimination of amoxicillin.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 18
• Est. completion date: June 2007
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 6 Years to 50 Years

Eligibility

Inclusion Criteria for Children:

• Urinary tract infection (UTI) treated with cefaclor or amoxicillin

Inclusion Criteria for Adults:

• No UTI

Exclusion Criteria:

• Allergies to antibiotics

• Use of medications other than oral contraceptives

• Pregnancy or breast-feeding

• Smoker

Study Design

Allocation: Non-Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Urinary Tract Infections

Intervention

Drug:
• Cranberry juice

• Amoxicillin

Locations

Country	Name	City	State
United States	University of Washington	Seattle	Washington

Sponsors (1)

Lead Sponsor	Collaborator
National Center for Complementary and Integrative Health (NCCIH)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Drug Elmination
Secondary	Drug absorption