Use of Sildenafil for Treatment of Urinary Incontinence

Status Active, not recruiting

Clinical Trial Summary

The investigators goal is to develop medical treatments for stress/mixed urinary incontinence. Sildenafil has been shown to improve blood flow as well as muscle mass and strength and to decrease muscle fatigue. The investigators believe that it will improve muscular atrophy in the pelvic floor, thus improving symptoms of urinary incontinence related to pelvic floor dysfunction.

Clinical Trial Description

Aim: To determine the effect of sildenafil on urinary incontinence. 1. Episodes of urinary incontinence will be recorded using a 3 day bladder diary. 2. Quantitative assessment of urinary incontinence will be performed at baseline and after treatment using a Pad Test. 3. Muscle strength will be assessed through use of a perineometer. 4. To evaluate macrocirculatory blood flow in pelvic organs, women will be assessed with noninvasive imaging before and after randomization to sildenafil. 5. Secondary outcomes will include evaluation of muscle and vaginal mucosal thickness. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02983461
Study type	Interventional
Source	The University of Texas Medical Branch, Galveston
Contact
Status	Active, not recruiting
Phase	Phase 1
Start date	March 10, 2017
Completion date	July 2025

View Details

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