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Correlation Between Changes in Sex Hormone Levels and Stress Urinary Incontinence in Women

Urinary Incontinence,Stress Clinical Trial

Official title:
Study on the Correlation Between Changes in Steroid Hormone Levels and Stress Urinary Incontinence in Women

Clinical Trial Summary

The goal of this observational study is to learn about the relationship between stress urinary incontinence and endogenous steroids in women, especially its occurrence and severity with androgens and estrogens. The main questions it aims to answer are: - Association between stress urinary incontinence and endogenous steroids in women - Risk factors associated with stress urinary incontinence in women Participants will be asked to provide basic clinical information as well as results of measurements of serum steroid hormone levels. Researchers will compare Stress urinary incontinence group and control group to see if the changes of sex hormone levels were statistically significant.

Clinical Trial Description

By comparing the differences of six hormones between female patients with stress urinary incontinence (SUI) and non-SUI patients (patients without pelvic floor muscle dysfunction and lower urinary tract dysfunction) aged ≥20 years, especially the changes of androgen and estrogen levels, the correlation between the changes of hormone levels and stress urinary incontinence was obtained. Multivariate logistic regression analysis was used to analyze the relationship between hormones and urinary incontinence, and further correlation analysis was performed for statistically significant hormones. Estrogen and androgen were divided into four groups: normal estrogen/normal androgen group, decreased estrogen/normal androgen group, normal estrogen/decreased androgen group, decreased estrogen/decreased androgen group. Stratified analysis was performed to analyze whether there was an interaction between the two hormones and exclude confounding effects. Finally, the data were further analyzed by sensitivity analysis of baseline characteristics, and the known risk factors were verified in this trial, including age, parity, menopausal status, genetic factors, obesity, and on this basis, the correlation between pelvic surgery history, diabetes, hypertension, smoking and stress urinary incontinence was explored. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06109623
Study type Observational
Source RenJi Hospital
Contact Zhang Jing-Yan
Phone +8619117170882
Email windsor0525@163.com
Status Not yet recruiting
Phase
Start date November 15, 2023
Completion date December 1, 2023
View Details
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